Nature
August 1, 2024
Joshua S. Siegel, Subha Subramanian, Demetrius Perry et al.
241 citations
A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5-8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here...
Annual Review of Neuroscience
May 4, 2015
Marcus E. Raichle
4,082 citations
The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its discovery was an unexpected consequence of brain-imaging studies first performed with positron emission tomography in which various novel,...
Proceedings of the National Academy of Sciences
February 21, 2012
Hanbing Lu, Qihong Zou, Hong Gu et al.
627 citations
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between...
Advances in Consciousness Research
October 28, 2010
Biyu J. He, Marcus E. Raichle
We propose a neurophysiological hypothesis on the emergence of consciousness, which postulates that the slow cortical potential (SCP) recorded from the surface of the brain provides an index of the activities of superficial-layer pyramidal neurons that directly contribute to the emergence of conscious awareness. This hypothesis is supported by existing data from manipulations of conscious...
Biological Psychiatry
October 15, 2009
Yvette I. Sheline, Marcus E. Raichle, Abraham Z. Snyder et al.
608 citations
BackgroundImportant functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Abeta) plaque-associated neuronal toxicity. Here, we sought to determine if pathological effects of Abeta amyloid plaques could be seen, even in the absence of a task, by examining functional connectivity in cognitively normal participants with...
Trends in Cognitive Sciences
June 15, 2009
Biyu J. He, M. Raichle
As functional magnetic resonance imaging (fMRI) has become a driving force in cognitive neuroscience, it is crucial to understand the neural basis of the fMRI signal. Here, we discuss a novel neurophysiological correlate of the fMRI signal, the slow cortical potential (SCP), which also seems to modulate the power of higher-frequency activity, the more established neurophysiological correlate of...
Proceedings of the National Academy of Sciences
January 16, 2001
Marcus E. Raichle, Ann Mary MacLeod, Abraham Z. Snyder et al.
12,440 citations
A baseline or control state is fundamental to the understanding of most complex systems. Defining a baseline state in the human brain, arguably our most complex system, poses a particular challenge. Many suspect that left unconstrained, its activity will vary unpredictably. Despite this prediction we identify a baseline state of the normal adult human brain in terms of the brain oxygen...