Background Cannabis (Δ 9 -THC) is the most commonly consumed illicit drug. The Agricultural Improvement Act of 2018 removed hemp, a strain of Cannabis sativa , as a controlled substance. This law allowed the plant to be processed into its components, which contain <0.3% Δ 9 -THC. As a result, delta-8-tetrahydrocannabinol (Δ 8 -THC), a federally unregulated substance, grew in popularity in 2020....
Salud, Ciencia y TecnologíaFebruary 19, 2023Roberto Carlos Mora Vera, Rosa Elizabeth Solorzano Bernita, Jorge Andrés Lozano Aveiga et al.2 citations
Introduction: schizophrenia is a chronic mental disease affecting around 24 million people worldwide. Within this disease, it is common to find the consumption of psychoactive substances by patients, with cannabis ranking first on the list; this drug bears a particular relation to schizophrenia through the effects of the cannabinoids proper to that plant. Objective: determine the relationship...
Previous evidence suggests that prenatal exposure to THC (pTHC) derails the neurodevelopmental trajectories towards a vulnerable phenotype for impaired emotional regulation and limbic memory. Here we aimed to investigate pTHC effect on hippocampus-related cognitive functions and markers of neuroplasticity in adolescent male offspring. Wistar rats were exposed to THC (2 mg/kg) from gestational...
Adolescent exposure to cannabinoids as a postnatal environmental insult may increase the risk of psychosis in subjects exposed to perinatal insult, as suggested by the two-hit hypothesis of schizophrenia. Here, we hypothesized that peripubertal Δ9-tetrahydrocannabinol (aTHC) may affect the impact of prenatal methylazoxymethanol acetate (MAM) or perinatal THC (pTHC) exposure in adult rats. We...
Background A dissociative subtype of posttraumatic stress disorder, known as “D-PTSD”, has been included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In addition to meeting criteria for PTSD, patients endorse prominent dissociative symptoms, namely depersonalization and derealization, or detachment from one's self and surroundings. At present, this population is...
Background Little is known about the frequency with which different combinations of phytochemicals (chemovars) arise in Cannabis flower or whether common chemovars are associated with distinct pharmacodynamics and patient health outcomes. This study created a clinically relevant, user-friendly, scalable chemovar indexing system summarizing primary cannabinoid and terpene contents and tested...
Abstract Background and Aims Long‐term harms of cannabis may be exacerbated in adolescence, but little is known about the acute effects of cannabis in adolescents. We aimed to (i) compare the acute effects of cannabis in adolescent and adult cannabis users and (ii) determine if cannabidiol (CBD) acutely modulates the effects of delta‐9‐tetrahydocannabinol (THC). Design Randomised, double‐blind,...
ABSTRACT Traumatic brain injury (TBI) is an important cause of mortality and morbidity worldwide. Cannabis use disorder and psychosis are rare but serious comorbidities seen after TBI. Recent studies indicate that the use of cannabis for self-medication may increase after TBI. Schizophrenia-like psychosis (SLP) is also seen, generally showing a late and gradual onset after TBI. Especially in...
Cannabis consumption during adolescence is an area of particular concern, owing to changes in the social and political perception of the drug, and presents a scientific, medical, and economic challenge. Major social and economic interests continue to push toward cannabis legalization as well as pharmaceutical development. As a result, shifting perceptions of both legal and illicit cannabis use...
Despite the high prevalence of polysubstance use, outcomes and potential risks associated with common drug combinations are not well characterized. Many individuals who use cocaine also use cannabis, yet little is known about how interactions between the two drugs might contribute to continued co-use. The aim of this double-blind, placebo-controlled study was to determine the physiological and...