Delta-8-THC association with psychosis: A case report with literature review
Frontiers in Psychiatry February 20, 2023 Chelsea R. Miller, Bradley G. Burk, Rachel E. Fargason et al. 16 citations
Three patients who regularly used only delta-8-tetrahydrocannabinol (Δ8-THC), a federally unregulated cannabis derivative, developed psychotic and paranoid symptoms severe enough to require admission to a university psychiatric hospital. The symptoms exceeded the severity of their previous psychiatric episodes and included new-onset violence and visual hallucinations in two patients, including one with no prior psychiatric history and one on a therapeutic antipsychotic dose. A third patient developed bizarre, fixed delusions of puppies dissolving in the bathtub. The report documents a temporal association between Δ8-THC use and psychosis, though conclusions are limited by reliance on self-reported use and possible confounding factors.