CNS Drugs
May 1, 2024
Libat Weizman, Haggai Sharon, Lior Dayan et al.
Disordered autonomic nervous system regulation and supraspinal pain inhibition have been repeatedly described in chronic pain. We aimed to explore the effects of δ-9-tetrahydrocannabinol (THC), an emerging treatment option, on autonomic nervous system and central pain modulation measures in patients with chronic pain. Twelve male patients with chronic radicular neuropathic pain participated in...
American Journal on Addictions
May 1, 2024
Michael Rogan, Julio C Nunes, Catherine Z Xie et al.
2 citations
Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta-9-tetrahydrocannabinol (THC) effects. This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD). Greater CT was associated with lower aversive effects from higher THC...
Substance Use & Misuse
April 25, 2024
D. Rubin-Kahana, Kevin Butler, A. Hassan et al.
Abstract Background With increases in cannabis use and potency, there is a need to improve our understanding of the impact of use on cognitive function. Previous research indicates long-term cannabis use may have a negative effect on executive function. Few studies have examined persistence of it in protracted abstinence, and there is limited evidence of predictors of worse cognitive function...
Frontiers in Psychiatry
April 23, 2024
Kennadi Johnson, A. Weldon, Melissa A. Burmeister
Schizophrenia is a serious mental health disorder that confers one of the highest mortality rates of all psychiatric illnesses. Although the disorder’s psychotic symptoms are treatable with conventional antipsychotics, they remain incurable. Moreover, medication adherence is poor, and individuals with schizophrenia choose to self-medicate with illicit substances, including cannabis. It is...
Scientific Reports
April 22, 2024
Oleh Durydivka, Petr Palivec, Matej Gazdarica et al.
7 citations
Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment of patients with neurological or psychiatric disorders. In many instances, treatment goals include relief from posttraumatic disorders, anxiety, or to support treatment of chronic pain. Ligands acting on cannabinoid receptor 1 (CB1R) are also potential targets for the...
BMC Psychiatry
April 19, 2024
Feten Fekih Romdhane, Amthal Alhuwailah, Hanaa Shuwiekh et al.
4 citations
BACKGROUND: Public education efforts to address and reduce potential harms from cannabis use in Arab countries are either slow or inexistent, and do not follow the steadily increasing trends of cannabis use in Arab youth. Several decades of research on substance use, it can be suggested that being aware of, and knowing about, psychosis risk related to cannabis can at least limit the consumption...
European Psychiatry
April 1, 2024
O. Martin-Santiago, M. Calvo-Valcarcel, P. Martinez.Gimeno et al.
Introduction Epidemiological studies have established a complex relationship between cannabis consumption and a heightened risk of psychotic disorders, including schizophrenia. However, this connection is multifaceted, influenced by genetics, environment, and individual psychology. Surprisingly, despite a surge in emergency room (ER) visits associated with cannabis consumption and psychosis,...
European Psychiatry
April 1, 2024
E. Bergaoui, R. Lansari, O. Chehaider et al.
IntroductionThe use of cannabis is associated with developing psychotic disorders, especially for those with a pre-existing vulnerability and elevated familial risk for psychosis.ObjectivesTo assess cannabis use during first episode psychosis and its relationship with patients’ clinical symptoms and functioning.MethodsWe assessed 50 patients hospitalized for first episode psychosis using three...
Theoretical and Natural Science
March 5, 2024
Hou-Yu Zhao, Kun Liang, Yiqun Fang
Military personnel and veterans experience distinct trauma exposures, resulting in totally different mental disorder prevalence, comorbidities, and treatment responses compared to the general population. The medical use of psychoactive substances as novel strategies for specific mental health conditions within military contexts is being investigated, while their therapeutic efficacy and safety...
Behavioral Sleep Medicine
March 3, 2024
Alannah Miranda, Elizabeth Peek, Sonia Ancoli-Israel et al.
Both sleep and cognition are partially modulated by the endocannabinoid (ECB) system. Cannabis has been reported to have effects on sleep and cognition. This review aims to summarize the recent literature on the ECB system, the role of cannabis and the ECB system on sleep regulation and cognition. Further, this review will identify existing gaps in knowledge and suggest potential targets for...