Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder.
Michael Rogan, Julio C Nunes, Catherine Z Xie, Mehmet Sofuoglu, Brian Pittman, Joao P De Aquino
The American Journal on Addictions May 1, 2024 DOI: 10.1111/ajad.13504 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Post-hoc analysis of a randomized, placebo-controlled, crossover trial Peer reviewed |
|---|---|
| Sample size | 25 |
| Population | Persons receiving methadone for opioid use disorder |
| Intervention | oral THC |
| Dose | 10, 20 mg |
| Topics | Addiction Cannabis |
| Citations | 2 |
| Key findings | Greater childhood trauma was associated with lower aversive effects from a 20 mg dose of THC. |
Abstract
Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta-9-tetrahydrocannabinol (THC) effects. This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD). Greater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006). CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD. These findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.
Comparable studies
Other randomized controlled trials on cannabis for addiction, most cited first.