Phencyclidine (1-[1-phenylcyclohexyl]piperidine, PCP, hog, sheets, angel dust, Sernylan, and many other common names) is a primate anesthetic that has emerged as a common drug of abuse and as a medical emergency problem during the past few years. Phencyclidine abuse is primarily a youthful activity. It is associated with multiple clinical states, an unusual amount of aggressive behavior, and a...
Editorials1 March 1979The Paradox of Phencyclidine (PCP) AbuseRICHARD STILLMAN, M.D., ROBERT C. PETERSEN, PH.D.RICHARD STILLMAN, M.D.Search for more papers by this author, ROBERT C. PETERSEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Sixty experienced marihuana smokers participated in a study designed to assess the effect of a negative expectancy on marihuana intoxication. Two different environments, threat of shock and no-threat, were used under the drug conditions of marihuana and placebo. Ss came into the laboratory and adjusted a level of shock received at their fingertips, to a point of mild discomfort. Only those Ss...
In a controlled study on 38 volunteers the effects of 250 micrograms/kg N,N-dimethyltryptamine (DMT) i.m. on objective and performance tests measuring psychoticism according to Eysenck were assessed. The hypothesis was tested that subjects treated with DMT (N = 26) differ from those receiving placebo (N = 12) in the same way as endogenous psychotics differ from normals. Confirmation was...
During the period 1971–1973, it was found that 53 out of 91 young drug abusers in a psychiatric hospital had experienced flashbacks. This applied to as many as 50 out of the 65 patients who had used LSD, but also to abusers of organic solvents and cannabis. As many as 38% of the patients were found to be severely incapacitated by their flashbacks. On a personal follow-up 1 1/2–4 years after the...
9 Ss were requested to perceive simultaneously the taste of beer and a rhythmic sound, the pitch of which could be varied. The frequencies at which Ss experienced harmony between the taste and the sound were determined. At the pitch of harmony Ss reported characteristic experiences, e.g., optimum taste of the beer, rhythmic sensations in the head, and tickling sensations in the jaws and the...
Herbal preparations, designed to be smoked or ingested for "health and happiness", are promoted as legal hallucinogens, euphoriants, and marihuana substitutes. A total of 25 psychoactive substances have been identified in these products, and a number of intoxications have resulted from their short- or long-term use. Physicians should be alerted to the nature of these effects when taking drug...
The author describes a model of intoxicant use based on altered states of consciousness and reviews his own and others' research on marijuana to illustrate the utility of this model, which is derived from both introspective reports and observed data. The relationship of social behavior and cognitive functioning to the "intoxication state of consciousness" is discussed. This state of...
At a dose as low as 1 microgram per kilogram of body weight, lysergic acid diethylamide (LSD) significantly decreased the suppressive effect of electric shock on licking behavior of the rat. Attenuation of punishment was also obtained with mescaline, but neither dimethyltryptamine nor Δ 9 -tetrahydrocannabinol was active in this test. Cyproheptadine and α-propyldopacetamide, drugs that...
Given the controversy of the late 1960s and early 1970s over the possible induction of chromosomal damage by psycho-active agents like LSD and marihuana, the peyote study of Teplitz et al (p 299), is reassuring. It is, first of all, comforting to know that in vivo studies of agents that are possible chromosomal mutagens can produce, when properly designed and executed, clear-cut results....