In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid receptor activation. Cannabis has been historically used to relieve some of...
This Pulse Check is a report of national trends in illicit drug abuse and drug markets in the United States. The report draws on conversations with ethnographers and epidemiologists working in the drug field, law enforcement agents, and drug treatment providers across the United States. Information from each of these sources is summarized in narrative form broken down by drug type and presented...
This study employed the theory of planned behavior (TPB) to investigate the factors underlying intentions to use and use of LSD, amphetamine, cannabis, and ecstasy over 6 months in a sample of students ( N = 461). The TPB provided good predictions of both intentions (mean R 2 = .49) and behavior (mean R 2 = .45). Descriptive norms explained additional variance in intentions for all the drugs,...
Long-term abuse of delta-9-tetrahydrocannabinol (THC), the major psychoactive constituent of marijuana, produces behavioral and metabolic signs of frontal cortical dysfunction in humans; these effects persist even after short-term abstinence. Based on a preliminary finding that repeated administration of THC to rats reduces basal frontal cortical dopamine turnover (Jentsch et al. [1998]...
Prologue 1. Addicted to Nothingness: Narcotics and Literature 2. The Voice of the Blood: Transcendentalism and Anesthetic Revelation 3. The Time of the Assassins: Cannabis and Literature 4. Induced Life: Stimulants and Literature 5. The Imaginal Realms: Psychedelics and Literature Epilogue Bibliography Notes Acknowledgments Illustration Credits Index
The rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (NAc). Furthermore, long-term changes in these synapses may support the addictive process. Excitatory and inhibitory synapses are acutely inhibited by cannabinoids in the NAc, and endogenous cannabinoids (endocannabinoids) play a...
This review article draws the attention to the many species of plants possessing activity on the central nervous system (CNS). In fact, they cover the whole spectrum of central activity such as psychoanaleptic, psycholeptic and psychodysleptic effects, and several of these plants are currently used in therapeutics to treat human ailments. Among the psychoanaleptic (stimulant) plants, those...
MDMA ("Ecstasy") and its analogues such as MDE and MDA are amphetamine derivatives reported to produce an altered state with emotional overtones. Since more than ten years, ecstasy is after cannabis the most frequently used recreational drug by young adults, particularly in the so-called techno-scene. However, according to a recent survey there is an increasing trend for a revival of classic...
Series Preface. Preface. Acronyms, Abreviations and Symbols. About the Author. Introduction to Drug Trends, Control, Legislation and Analysis. Amphetamine and Related Compounds. The Analysis of LSD. Cannabis sativa and Products. Diamorphine and Heroin. Cocaine. Products from Catha edulis and Lophophora williamsii. The Analysis of Psilocybin and Psilocin from Fungi. The Analysis of Controlled...
Tetrahydrocannabinol (cannabis) and lysergic acid diethylamide (LSD) are psychomimetic agents that induce impairment of sensory perception. Illusions and hallucinations are mostly visual. Most frequently the visual phenomena occur in conjunction with drug abuse. Three previously drug-addicted patients were examined for either persisting or spontaneously recurrent visual phenomena. Two patients...