Behavioural Pharmacology
September 1, 2005
Aaron B Ilan, Alan Gevins, Michael J. Coleman et al.
165 citations
This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy marijuana users (12 men, 11 women) participated in four sessions. They were randomly assigned to a low or a high delta9-tetrahydrocannabinol group (THC; 1.8% versus 3.6%). In the four sessions under blinded conditions subjects smoked...
Neuropsychopharmacology
August 2005
June M Young, Iain S. Mcgregor, Paul E Mallet
3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy') and cannabis are two of the most commonly used illicit drugs in the western world, and are often used in combination. Very little research has examined their effect on cognitive function or behavior when combined, The present study used a double Y-maze task to examine the acute effect of MDMA and delta9-tetrahydrocannabinol (THC, the principal...
Journal of Analytical Toxicology
July 1, 2005
Annick Ménétrey, Marc Augsburger, Bernard Favrat et al.
89 citations
Delta(9)-Tetrahydrocannabinol (THC) is frequently found in the blood of drivers suspected of driving under the influence of cannabis or involved in traffic crashes. The present study used a double-blind crossover design to compare the effects of medium (16.5 mg THC) and high doses (45.7 mg THC) of hemp milk decoctions or of a medium dose of dronabinol (20 mg synthetic THC, Marinol on several...
Psychopharmacology
June 2005
Marcello Solinas, Steven R Goldberg
Many behavioral effects of delta-9-tetrahydrocannabinol (THC), including its discriminative-stimulus effects, are modulated by endogenous opioid systems. To investigate opioid receptor subtypes involved in the discriminative effects of THC. Rats trained to discriminate 3 mg/kg i.p. of THC from vehicle using a two-lever operant drug-discrimination procedure, were tested with compounds that bind...
Neuroimage
June 2005
Karen I Bolla, Dana A Eldreth, John A Matochik et al.
Persistent dose-related cognitive decrements have been reported in 28-day abstinent heavy marijuana (MJ) users. However, the neural substrates of these decrements in cognitive performance are not known. This study aimed to determine if 25-day abstinent MJ users show persistent dose-related alterations in performance and brain activity using PET H(2)(15)O during the Iowa Gambling Task-IGT (a...
Human psychopharmacology
June 2005
R M Milani, A C Parrott, F Schifano et al.
Cannabis is one of the most common 'co-drugs' for ecstasy users. The aim of the present study was to explore self-reported psychobiological problems in ecstasy polydrug users in relation to their pattern of cannabis use. Two hundred and eighty ecstasy polydrug users were allocated into five cannabis groups according to the frequency of their cannabis use. The control group comprised 121...
European Psychiatry
June 1, 2005
Anton Grech, Jim van Os, Peter B. Jones et al.
AbstractPurposeTo test the hypothesis that recent onset psychotic patients who use cannabis will have psychotic symptoms that are more severe and more persistent than those who do not use cannabis.Subjects and methodsWe carried out a 4-year follow-up study of a cohort of 119 patients with recent onset of psychosis. The patients were divided into four groups according to duration of cannabis...
Psychopharmacology
May 2005
Matthew Rizzo, C T J Lamers, C G Sauer et al.
Illicit drug use can increase driver crash risk due to loss of control over vehicle trajectory. This study asks, does recreational use of +/-3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) and tetrahydrocannabinol (THC; marijuana) impair cognitive processes that help direct our safe movement through the world? This study assesses the residual effects of combined MDMA/THC use, and of THC use...
Addiction
April 22, 2005
B Mirken, Mitch Earleywine
10 citations
Fergusson and colleagues assert that their results from a New Zealand cohort ‘add to the growing body of evidence that regular cannabis use may increase risks of psychosis’[1]. In fact, their study raises more questions than it answers. One obvious question is raised by their use of ten items from Symptom Checklist 90 as the only assessment tool for symptoms of psychosis. The items assessed...
Neuropsychopharmacology
April 2005
Scott D Lane, Don R Cherek, Oleg V Tcheremissine et al.
Previous studies have established a relationship between marijuana use and risky behavior in natural settings. A limited number of laboratory investigations of marijuana effects on human risk taking have been conducted. The present study was designed to examine the acute effects of smoked marijuana on human risk taking, and to identify behavioral mechanisms that may be involved in drug-induced...