The British Journal of Psychiatry
May 31, 2011
Maria Alice Fontes, Karen I Bolla, Paulo Jannuzzi Cunha et al.
300 citations
BACKGROUND: Many studies have suggested that adolescence is a period of particular vulnerability to neurocognitive effects associated with substance misuse. However, few large studies have measured differences in cognitive performance between chronic cannabis users who started in early adolescence (before age 15) with those who started later. AIMS: To examine the executive functioning of...
Neuroimage
June 2005
Karen I Bolla, Dana A Eldreth, John A Matochik et al.
Persistent dose-related cognitive decrements have been reported in 28-day abstinent heavy marijuana (MJ) users. However, the neural substrates of these decrements in cognitive performance are not known. This study aimed to determine if 25-day abstinent MJ users show persistent dose-related alterations in performance and brain activity using PET H(2)(15)O during the Iowa Gambling Task-IGT (a...
Drug and Alcohol Dependence
January 7, 2005
John A Matochik, Dana A Eldreth, Jean Lud Cadet et al.
Marijuana is the most widely used illicit substance in the United States; however, previous imaging studies have not detected altered brain structure in marijuana users compared to non-users. Voxel-based morphometry was used to investigate possible differences in brain tissue composition in a group of 11 heavy marijuana users and a group of 8 non-users. All participants were male. Statistical...
Neuroimage
November 2004
Dana A Eldreth, John A Matochik, Jean L Cadet et al.
We used PET (15)O and a modified version of the Stroop task to determine if 25-day abstinent heavy marijuana (MJ) users have persistent deficits in executive cognitive functioning (ECF) and brain activity. Performance on a modified version of the Stroop task and brain activity was compared between 25-day abstinent, heavy marijuana users (n = 11), and a matched comparison group (n = 11). The...
Neurology
December 1, 1998
Karen I Bolla, Una D. Mccann, George A. Ricaurte
376 citations
Abstinent MDMA users have impairment in verbal and visual memory. The extent of memory impairment correlates with the degree of MDMA exposure and the reduction in brain 5-HT, as indexed by CSF 5-HIAA.