Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
November 23, 2017
Peter Manza, Dardo G. Tomasi, Nora D. Volkow
61 citations
BACKGROUND: Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly with early age of initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated psychopathology, we hypothesized that regular CA would be associated...
CRC Press eBooks
November 22, 2017
Richard Bryant‐Jefferies
Charlotte is working with Ali, who is in his late teens. He is the son of Fareeda. His father is white, English and he has a younger brother, Adam. Her supervisor is Matt. Ali has been using cannabis for some years, and has begun using the stronger ‘skunk’ cannabis which is more powerful than the dope, grass and marihuana of previous years. It is difficult to know whether his cannabis use...
PLoS One
November 11, 2017
Ana González-Pinto, Itxaso González-Ortega, Susana Alberich et al.
The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working...
Journal of Neuroscience
November 8, 2017
Lindsey Friend, Jared Weed, Philip Sandoval et al.
The VTA is necessary for reward behavior with dopamine cells critically involved in reward signaling. Dopamine cells in turn are innervated and regulated by neighboring inhibitory GABA cells. Using whole-cell electrophysiology in juvenile-adolescent GAD67-GFP male mice, we examined excitatory plasticity in fluorescent VTA GABA cells. A novel CB1-dependent LTD was induced in GABA cells that was...
Scientific Reports
November 3, 2017
Sagnik Bhattacharyya, Alice Egerton, Euitae Kim et al.
Use of Cannabis, the most widely used illicit drug worldwide, is associated with acute anxiety, and anxiety disorders following regular use. The precise neural and receptor basis of these effects have not been tested in man. Employing a combination of functional MRI (fMRI) and positron emission tomography (PET), we investigated whether the effects of delta-9-tetrahydrocannabinol (delta-9-THC),...
Addiction
November 2017
Sarah D Lichenstein, Samuel Musselman, Daniel S Shaw et al.
(1) To identify trajectories of cannabis use across adolescence, (2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc) and (3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later. The Pitt Mother and Child Project (PMCP) is a prospective,...
Psychopharmacology
November 2017
Chandni Hindocha, Will Lawn, Tom P. Freeman et al.
Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing tobacco and/or cannabis use disorders. Currently, there is no human experimental research on how these drugs interact on addiction-related measures. This study aimed to investigate how cannabis and tobacco, each alone and combined together in joints, affected individuals'...
International Journal of Medical Research and Review
October 31, 2017
Rabindran Chandran, Mamta Verma, Associate Professor In Nursing Aiims Bhopal MP India
1 citation
Psychosis is a condition where there is a loss of contact with reality with symptoms like delusions, hallucinations, paranoia, disorganized thinking & speech, loss of motivation, depression, anxiety & poor sleep. It can be associated with Schizophreniform disorder, Bipolar disorder, Schizoaffective disorder, Depression with psychotic features, Drug-induced psychosis, Organic psychosis or...
International Journal of Medical Research and Review
October 31, 2017
D. V. Pal, Dr. Stuti Rastogi, Dr. Amrita Chauhan et al.
2 citations
Background: Therehas been plethora of research regarding cannabis use disorder but very few studies reported demographic and phenomenological differences of acute psychosis with cannabis use to those of acute psychosis without cannabis use. This study attempted to evaluate the demographic and phenomenology differences between two groups of patients presenting with acute psychosis with cannabis...
JMIR public health and surveillance
October 26, 2017
Elad Yom-Tov, Shaul Lev-Ran
Background: Cannabis is one of the most widely used psychoactive substances worldwide, but adverse drug reactions (ADRs) associated with its use are difficult to study because of its prohibited status in many countries. Objective: Internet search engine queries have been used to investigate ADRs in pharmaceutical drugs. In this proof-of-concept study, we tested whether these queries can be used...