January 12, 2024
Joshua Clingo
1 citation
preprint
Common mental health pathologies such as depression, anxiety, addiction, and PTSD have recently seen treatment inroads. These issues share a phenomenological core—a dissociative quality that involves the disintegration of self and other. Interestingly, some of the most effective treatments of these pathologies are themselvesacutely dissociative. For example, psychedelic therapy has been...
ACS Medicinal Chemistry Letters
January 11, 2024
Robert B. Kargbo
1 citation
Psychedelic compounds, including ketamine and LSD, have gained renewed interest as potential treatments for neuropsychiatric disorders. These compounds act as psychoplastogens, promoting neuronal growth by activating AMPA receptors, TrkB, and mTOR. The prefrontal cortex plays a crucial role in their therapeutic effects through top-down control over brain regions involved in motivation, fear,...
Research Square
January 4, 2024
Laetitia Vanderijst, Felix Hever, Anne Buot et al.
preprint
Abstract Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and...
Proceedings of the National Academy of Sciences
January 3, 2024
Carolyn Beans
Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice ...Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance....
JAMA Network Open
January 2, 2024
Asli Korkmaz, Guro Pauck Bernhardsen, Burcu Cirit et al.
24 citations
Physicians are exposed to high stress and strain that results in burnout, which affects them, their families, their patients, and the entire health care system; thus, there is an urgent need to develop methods to increase the resiliency of physicians. Sudarshan Kriya Yoga (SKY) is a comprehensive yoga breathing and meditation-based program that is a potential approach to mitigate physician...
Journal of Psychoactive Drugs
2024
Michael J Pellicane, Madison E Quinn, Christian A L Bean et al.
Use of delta-8-THC ("delta-8") has proliferated after the passage of the 2018 Farm Bill. Yet, research on the mental health effects of this increasingly popular cannabinoid is scant. The current study sought to examine mental health correlates of delta-8 use frequency and motives, investigate whether delta-8 use motives predict use frequency, and compare use motives and problems between delta-8...
Neuropsychopharmacology
January 2024
Jenessa N Johnston, Bashkim Kadriu, Christoph Kraus et al.
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the development of neuropsychiatric therapeutics, one characterized by an antidepressant response that occurred within hours or days rather than weeks or months. Considerable clinical research supports the use of-or further research with-subanesthetic-dose ketamine and its (S)-enantiomer esketamine in multiple...
The Social Science Review A Multidisciplinary Journal
2024
Bravishi Slag, Thokchom Dheerash, Ravindra Kumar
The impact of meditation on human well-being is positive in several ways. It is an ancient practice used by the people to gain the wellbeing. The meditation can make a human life better, improving their physical health, mental health, psychological health and spiritual health. The aim of the present study to review the impact of meditation on physical, mental and social wellbeing. The study on...
International Journal of Education and Social Science Research
2024
Asst. Prof Dr. Wasfi Dhahir Abid Ali
During sleep paralysis you may feel: awake but cannot move, speak or open your eyes, like someone is in your room, like something is pushing you down, frightened these feelings can last up to several minutes. Sleep paralysis happens when you cannot move your muscles as you are waking up or falling asleep. This is because you are in sleep mode but your brain is active. It's not clear why sleep...
Journal of Contemplative and Holistic Education
2024
Lee Fergusson, Javier Ortiz Cabrejos, Anna Bonshek et al.
The COVID-19 pandemic dealt a devastating blow to the social fabric of Perú, with the highest orphans per death (OPD) ratio of any country in Latin America. Therefore, 260,000 orphans now require care because of 216,000 parent, custodial grandparent, and caregiver deaths between 2020 and 2022. The purpose of this research is to examine whether the practice of Transcendental Meditation, an...