November 18, 2024
Yair Dor-Ziderman, Jonathan David, Aviva Berkovich-Ohana
preprint
There is a growing hype regarding the efficacy of psychedelics to fundamentally change how we interact with the theme of death. The underlying evidence consists of anecdotal and self-report data collected in naturalistic and clinical settings suggesting that psychedelics inculcate more acceptance and less fear and anxiety of one’s mortality. However, given hundreds of empirical studies...
International Journal for Research in Applied Science and Engineering Technology
November 17, 2024
Raj Nashikkar, Kavita Mane, Rajendra Patil
1 citation
Abstract: Psilocybin mushrooms, also known as "magic mushrooms," have garnered significant attention for their psychoactive properties and potential therapeutic applications. This review explores the comprehensive morphology, pharmacognostic properties, and pharmacological activities of psilocybin-producing fungi. The unique morphological characteristics of these mushrooms, including their...
Psychotherapy Research
November 17, 2024
Zhenzhen Wang, Xinyi Tang, Amy Hu et al.
5 citations
To investigate the role of decentering as a mediator of the effect of mindfulness/mindfulness-based intervention (MBI) on emotional distress, we conducted cross-sectional and longitudinal designs. In Study 1, a total of 998 participants with high emotional distress were included. Mindfulness, decentering, anxiety, and depression were measured at baseline. In Study 2, 688 participants with high...
Schizophrenia Bulletin
November 16, 2024
Inge Hahne, Marco Zierhut, Niklas Bergmann et al.
3 citations
The efficacy of yoga as an adjunctive treatment for schizophrenia spectrum disorders (SSD) has garnered interest. While yoga may positively influence various symptom domains, further investigation is needed due to the limited number, quality, and generalizability of studies. This study assessed the feasibility and acceptability (primary outcome) of a yoga-based group intervention (YoGI)...
Science
November 15, 2024
Jessie Muir, S Lin, Isak K Aarrestad et al.
37 citations
Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specific neurons modulated by a psychedelic to determine their role in driving behavior. Using a light- and calcium-dependent activity integrator, we genetically tagged psychedelic-responsive neurons in...
Biomedicines
November 15, 2024
Andrea Calderone, Desirèe Latella, Federica Impellizzeri et al.
83 citations
Background and Objectives: Meditation and mindfulness, rooted in ancient traditions, enhance mental well-being by cultivating awareness and emotional control. It has been shown to induce neuroplasticity, increase cortical thickness, reduce amygdala reactivity, and improve brain connectivity and neurotransmitter levels, leading to improved emotional regulation, cognitive function, and stress...
ACS Medicinal Chemistry Letters
November 14, 2024
Robert B. Kargbo
3 citations
Recent advancements in the therapeutic use of psychedelic compounds, particularly 5-MeO-DMT and DMT, have demonstrated significant potential in treating various mental health disorders. This Patent Highlight evaluates findings from multiple recent patents that explore novel applications of these compounds, including their use in severe psychiatric conditions such as depression, anxiety, and...
International Journal of Environmental Research and Public Health
November 13, 2024
Rebecca Ciacchini, Ciro Conversano, Graziella Orrù et al.
5 citations
Chronic pain (CP) affects about 30% of the global population and poses significant challenges to individuals and healthcare systems worldwide. The interactions between physiological, psychological, and social factors are crucial in the onset and development of CP conditions. This study aimed to evaluate the effectiveness of mindfulness-based intervention, examining its impact on perceived...
ACS Medicinal Chemistry Letters
November 11, 2024
Robert B. Kargbo
High Resolution Image Download MS PowerPoint Slide Recent innovations in psychedelic research have led to the development of novel compounds designed to enhance the therapeutic potential of psilocin and related tryptamines. This Patent Highlight reviews three essential patents that focus on improving the stability, bioavailability, and efficacy of these compounds for treating mental health...
Psychoactives
November 8, 2024
Jonathan Tran, Aaron Elkins, Simone Vassiliadis et al.
1 citation
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior. A subclass of psychoactive drugs, psychedelics, are hallucinogenic drugs that can trigger psychedelic experiences and possible changes in mental perception. The potential use of psychedelics as a therapeutic has led to an increase in clinical...