Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite a history of stigmatization and restriction in use. The present review synthesizes existing literature on the therapeutic potential of psychedelics such as LSD, psilocybin, and MDMA in addressing specific mental health conditions like depression, anxiety, and addiction. On reviewing...
Journal of American College HealthApril 22, 2025Laura García-pérez, Maria Elena Atencia-Rodriguez, Mar Cepero-González et al.8 citations
University students face mental health (MH) issues like anxiety, depression, and stress, highlighting the need for effective interventions to improve well-being and academic success. This review examined 18 randomized controlled trials (RCTs) from 2000 to 2023, following PRISMA guidelines. A total of 2,325 students, aged 18-25 without severe MH conditions, participated in physical activity (PA)...
Introduction: Ketamine is an evidenced-based treatment for depression, and it has shown promise in addressing many other mental health conditions related to work-related stress or burnout, such as anxiety and post-traumatic stress disorder. Ketamine-assisted psychotherapy (KAP) is part of an emerging model of psychedelic medicine that employs psychoactive agents to support the psychotherapeutic...
Abstract 5-MeO-DMT, a potent, short-acting psychedelic, induces profound shifts in cognition, affect, and self-awareness. Because language explicitly expresses these domains and voice implicitly conveys them, both may serve as potential ‘biomarkers’ of behavioural change. This study introduces a novel framework for analysing baseline language and vocal features, pre- to post-psychedelic...
Emerging evidence suggests that psychedelic experiences have the potential to change attitudes towards death and reduce death anxiety. Improved attitudes towards death, specifically reduced death anxiety, are of psychological significance for clinical and non-clinical populations alike. Despite this emerging evidence, little is known about the phenomenology of this potential outcome. To provide...
Microdosing is the practice of taking psychedelic drugs at doses that produce no or minimal perceptible subjective or behavioural effects. This study investigated the pharmacokinetics and pharmacodynamics of microdosed lysergic acid diethylamide (LSD). This was a Phase 1 double-blind placebo-controlled parallel-groups trial with 80 healthy male volunteers (four withdrawals due to anxiety)....
Psilocybin, the prodrug to the psychoactive compound in 'magic' mushrooms, is currently being studied in clinical trials as a treatment for severe mental health conditions, such as depression and anxiety. Previous reports of psilocybin biosynthesis as reconstituted in E. coli reported maximum titers of 1.16 g/L, exclusively using genes from the most common recreationally used mushroom,...
Meditation, traditionally seen as a path to spiritual enlightenment, is commonly used in therapeutic contexts for its mental health benefits, such as reducing stress, anxiety, and depression. However, alongside these benefits, practitioners of diverse forms of meditation have repeatedly been reporting adverse effects (AEs) of meditation. While most of these AEs are transient, some of them are...
To investigate the effects of the Mindfulness-Based Health Promotion (MBHP) program on quality of life (QOL) and well-being in older adults compared to an active control group. A randomized controlled trial nested within a cohort study was conducted. Participants were allocated to either the MBHP intervention or an active control group (ACG) receiving computer-based cognitive stimulation....
The Physical and Psychological Effects of MeditationPari Patel Meditation has many physical and psychological effects on the human body.Meditation originated from ancient Eastern culture and has been practiced for centuries.Meditation back then was considered a religious practice; however, it is not necessary to be religious to meditate.Trials conducted and respected research show that...