Journal of Affective Disorders
August 15, 2025
Xinya Hong, Sen Xu, Gaozhong Sun et al.
3 citations
This multicenter, randomized, placebo-controlled, clinical trial was designed to investigate the efficacy and safety of esketamine (ESK) for smoking cessation. The study enrolled a sample of 236 patients diagnosed with lung cancer and major depression disorder (MDD). Treatment included intranasal delivery of ESK or placebo once a week for 8 sessions. The primary outcomes were self-reported and...
Brazilian Journal of Implantology and Health Sciences
August 14, 2025
A. Silva, Érika Barros Teixeira da Cruz, Samuel Cândido Freres et al.
O transtorno de estresse pós-traumático (TEPT) é uma condição psiquiátrica caracterizada por sintomas persistentes após vivência de eventos traumáticos, incluindo revivescências, hipervigilância e esquiva. Estudos recentes têm apontado o uso de psicodélicos, como MDMA e psilocibina, como potenciais coadjuvantes no tratamento, devido à sua capacidade de promover neuroplasticidade e facilitar a...
International Journal of Progressive Research in Engineering Management and Science
August 12, 2025
The abstract for the article "Finding Harmony Within: How Meditation Enhances Emotional Stability and Strength" aims to explore the transformative power of meditation in fostering emotional well-being and resilience.In today's fastpaced, often stressful world, individuals increasingly seek ways to manage their emotions, reduce stress, and cultivate inner peace.With its ancient roots in...
The International Journal of Neuropsychopharmacology
August 11, 2025
Gihyun Yoon, Brian Pittman, E. Ralevski et al.
IMPORTANCE The comorbidity of major depressive disorder (MDD) and alcohol use disorder (AUD) is often treated inadequately. This study evaluated the impact of adding the opioid receptor blocker, naltrexone, to the NMDA glutamate receptor antagonist, ketamine, for the treatment of MDD comorbid with AUD. In so doing, it also attempted to shed light on the contribution of opioid receptor...
Psychiatry and Clinical Psychopharmacology
August 11, 2025
Lisa Burback, Olga Winkler, Rakesh Jetly et al.
Traditional trauma-focused psychotherapies (TFPs) were developed based on an anxiety disorder model of posttraumatic stress disorder (PTSD). However, PTSD is a more complex disorder with heterogeneous onset, presentation, trajectory, and treatment responsivity. As half of treated patients do not respond to first-line treatments, innovative therapies are emerging to improve outcomes. This...
International Journal For Multidisciplinary Research
August 10, 2025
Pavleen Kour, Ramaiyan Velmurugan, Lily Podder
Family members of ICU patients often experience significant psychological distress, including anxiety, depression, and stress, which can affect their well-being and coping ability. Mindfulness meditation has shown promise in alleviating such distress, but its effect on ICU patient families remains underexplored. This quasi-experimental study evaluated the impact of a 14-day mindfulness...
Current Opinion in Psychology
August 6, 2025
Iva Totomanova, Eline Haijen, Petra P M Hurks et al.
5 citations
Microdosing psychedelics, the regular use of low doses of LSD or psilocybin, have attracted growing public and scientific interest. This review synthesizes findings from 57 human studies on psychological and physiological outcomes in clinical and non-clinical populations. Reported benefits include improved mood, enhanced cognition, social functioning, and mental health, although findings are...
Galen Medical Journal
August 5, 2025
Shingo Ueda
Recent advances in neuroscience have revealed a significant interplay between the neuropeptide oxytocin and the brain’s Default Mode Network (DMN), suggesting a pivotal role in modulating attachment and self-referential processing. This review synthesizes current findings from neuroimaging, behavioral studies, and clinical research to explore the “oxytocin-DMN axis” and its impact on social...
Entropy (Basel, Switzerland)
August 4, 2025
Don M Tucker, Phan Luu, Karl Friston
The organization of consciousness is described through increasingly rich theoretical models. We review evidence that working memory capacity—essential to generating consciousness in the cerebral cortex—is supported by dual limbic memory systems. These dorsal (Papez) and ventral (Yakovlev) limbic networks provide the basis for mnemonic processing and prediction in the dorsal and ventral...
International Journal of Molecular Sciences
August 4, 2025
Masahide Arinaga, Jun Yamada, Shoichiro Maeda et al.
2 citations
Cancer-related cognitive impairment (CRCI)-encompassing anxiety, depression, and memory deficits-significantly diminishes the quality of life in patients with cancer, yet remains underrecognized in clinical practice. In this study, we investigated the therapeutic potential of tabernanthalog (TBG), a non-hallucinogenic analog of psychedelic compounds, as a novel intervention for CRCI using a...