Importance: Depression most commonly first emerges during adolescence, making early prevention critical. While school-based mindfulness training (SBMT) offers a scalable prevention approach with broad reach, evidence of its effectiveness is mixed, and there is a compelling case for a more personalized approach to prevention. Objective: To develop a data-driven algorithm from baseline...
Our thoughts are the foundations for wellbeing and happiness. One must practice regulating his/her thoughts to manage Stress. Stress may be conceptualized as a form of mental fatigue, characterized by difficulties in forward thinking, an inability to maintain focus, reduced clarity, and a diminished motivation to engage with tasks. Within this framework, ignorance is understood as a lack of...
Open MindFebruary 22, 2026Yoesoep Edhie Rachmad
preprint
The twenty-first century has produced a paradox unprecedented in human history: never before has humanity been so hyperconnected, yet never before has it experienced such widespread existential fragmentation. Digital networks collapse geographic distance, algorithmic systems personalize information flows, and virtual environments simulate immersive realities. Yet amid this technological...
Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in treating depression, anxiety, post-traumatic stress disorder, substance use, eating, and personality disorders. Preclinical work shows enhanced neuroplasticity, reduced inflammation, and oxidative stress. Human neuroimaging reveals decreased default...
Background: Patients with psoriasis often experience emotional distress, which may be alleviated through psychological interventions. Objective: To evaluate online Mindfulness-Based Cognitive Therapy (MBCT) as an adjuvant treatment for psoriasis, focusing on severity of lesion, anxiety, depression, quality of life, and itching. Methods: This randomized trial enrolled 109 patients with psoriasis...
Background: Meditation is a mental practice in which a person intentionally focuses their mind on a particular object, thought, sensation or awareness to cultivate calmness, clarity, emotional balance and heightened consciousness. Meditation significantly influences the autonomic nervous system by reducing sympathetic activity and enhancing parasympathetic activity. Aim: The present study was...
BackgroundA range of singing interventions exist for mental health contexts, but few have incorporated group-based body, breathwork and vocal improvisation. The Feldenkrais method has potential to support singing interventions by raising attention to body and breath. This study aimed to describe practice and evaluate experiences and outcomes of a Feldenkrais and group vocal improvisation...
This chapter explores the growing frontier of virtual reality meditation (VRM), which blends ancient contemplative practices with immersive digital environments. By putting on a headset, users can find themselves in a Zen garden, forest, or mountaintop dojo, where guided breathing is paired with visuals, sounds, and even interactive features that make meditation more engaging and intuitive....
Ketamine has emerged as a promising intervention for treatment-resistant mental health disorders, such as depression, anxiety, and posttraumatic stress disorder. With rising global mental health burdens and the limitations of existing pharmacological treatments, ketamine's novel mechanism of action provides a potential alternative for individuals who have not responded to traditional therapies....
medRxivFebruary 19, 2026Amanda Gow, Emily Shih, Ryan Reid et al.
preprint
Abstract Background In 2020, Oregon became the first U.S. state to establish a regulated framework for adults to access psilocybin services using naturally-derived mushroom products. No studies have examined mental health outcomes among individuals receiving psilocybin in this context. Aims To evaluate changes in self-reported symptoms of depression, anxiety, and well-being 30-days...