This paper follows 8 scientists who ventured into the world of psychedelics on a quest to find transformational pathways forward. Each have worked on aspects of global environmental change for decades, and observing environmental crises converging into a global polycrisis/metacrisis with genuine potential for collapse, we have all carried psychological burdens, including fatigue, anxiety,...
Correction 1: Table 1.The analyses were conducted using the correct data, and all results, interpretations, and conclusions in the paper remain fully accurate.The issue is limited to the presentation of values in the table.Correction 2: p 4733, second paragraph, 1 st sentence.Thigmotaxis was evaluated to assess potential anxiety-like effects induced by the compounds.When comparing the tested...
Background: The Default Mode Network (DMN) is consistently implicated in self-referential thinking and rumination and shows altered functioning in depression and anxiety disorders. The Attention Training Task (ATT), a core technique in metacognitive therapy, aims to reduce internally directed attention by enhancing flexible attentional control. While previous neuroimaging studies have...
Methods and ProtocolsMarch 3, 2026Aglaia Zafeiroudi, Ioannis Tsartsapakis, Charilaos Kouthouris
Recreational dance offers significant psychological well-being potential. However, traditional instruction emphasizes technique while limiting attention to nervous system development and embodied meaning-making. Despite empirical support for polyvagal theory, motor learning science, somatic education, and phenomenology, their systematic integration into unified structures is not clearly...
A 16-year-old boy with severe obsessive-compulsive disorder (OCD), characterized by health-focused obsessions, intrusive ruminations, derealization, and significant functional impairment, failed to tolerate standard serotonergic agents (escitalopram, fluoxetine) and bupropion due to worsening anxiety, somatic concerns, or headaches. An oral glutamatergic regimen was initiated with...
Background: Depression in children is a concerning societal issue and can be associated with poor academic performance, school dropout, and poor overall quality of life. Additionally, child depression is often associated with parallel stress and depression in parents. Objective: This scenario highlights the urgent need for the development and implementation of accessible and scalable solutions...
This study investigated the impact of mindfulness meditation (MM) nursing on outcomes of in vitro fertilization-embryo transfer (IVF-ET). A total of 100 infertile patients undergoing IVF-ET were randomly assigned to either a conventional care group or an MM group, with 50 patients in each. While both groups received routine nursing, the MM group received additional MM-based nursing...
Ketamine is a powerful and rapid-acting antidepressant but has no regulatory authorization for any psychiatric illness. The S-enantiomer of ketamine, esketamine, was approved by the FDA in 2019 as adjunctive therapy for treatment-resistant depression. Substantial controversy exists as to whether there is a significant clinical difference between intravenous (IV) ketamine racemate and intranasal...
March 1, 2026Brian Joel Sapulette, Ida Ayu Mas Prabhasuari, Humairatun Zakiyah et al.
Purpose of Review: Adolescents are vulnerable to mental health issues, affecting approximately 14% globally. Mindfulness interventions have shown effectiveness in addressing these issues and offer positive benefits across various domains. This review explores the outcomes of mindfulness therapy for adolescents with mental health problems. Collection and Analysis of Data: This scoping review...
Online Mindfulness-Based Cognitive Therapy (MBCT) is a promising intervention for mental health, but its effectiveness in reducing depressive symptoms remains underexplored. While key mechanisms of change have been identified in traditional MBCT, their role in online delivery formats needs further investigation. This study aimed to evaluate the effectiveness of synchronous and asynchronous...