IMPORTANCE: As psychedelic-assisted therapies gain clinical legitimacy, their cultural portability remains underexamined. While promising results have emerged from trials on existential distress in life-limiting illness, most protocols reflect Euro-American values. The expansion of these therapies calls for a pivot toward cultural humility and renewed attention to what constitutes a "good...
Psychedelic-assisted therapies (PATs) can produce rapid and sustained antidepressant effects, yet variability in response remains substantial. Identifying predictors and moderators is essential for optimising patient selection, preparation, and delivery. To map and synthesise the evidence on the predictors of antidepressant response to classic/serotonergic psychedelics administered with...
Ketergantungan pada ponsel pintar atau Nomophobia (No Mobile Phone Phobia) telah menjadi tantangan kesehatan mental yang signifikan bagi Generasi Z, termasuk siswa di lingkungan pesantren. Penelitian ini bertujuan untuk menguji efektivitas integrasi Islamic Mindfulness (Muraqabah) sebagai intervensi psikologis untuk menurunkan tingkat nomophobia pada siswa SMA Daruttaqwa Gresik. Muraqabah,...
Objectives: This study describes the collaborative design and implementation of the Indigenous MIND (IM) program, a culturally adapted mindfulness intervention developed in partnership with Indigenous communities in the USA. The aim was to explore the program's acceptability and cultural resonance and to document the processes by which IM evolved in each of our partner communities and explore...
Psychological stress not only undermines quality of life for people with cancer but also fuels tumor growth. Emerging evidence from the nascent field of cancer neuroscience suggests that adrenergic signaling from direct tumor-neuron interactions drives cancer progression, resistance to treatment, and worse outcomes. Cancer neuroscientists are increasingly seeking to repurpose psychoactive...
Importance: Depression most commonly first emerges during adolescence, making early prevention critical. While school-based mindfulness training (SBMT) offers a scalable prevention approach with broad reach, evidence of its effectiveness is mixed, and there is a compelling case for a more personalized approach to prevention. Objective: To develop a data-driven algorithm from baseline...
Our thoughts are the foundations for wellbeing and happiness. One must practice regulating his/her thoughts to manage Stress. Stress may be conceptualized as a form of mental fatigue, characterized by difficulties in forward thinking, an inability to maintain focus, reduced clarity, and a diminished motivation to engage with tasks. Within this framework, ignorance is understood as a lack of...
Open MindFebruary 22, 2026Yoesoep Edhie Rachmad
preprint
The twenty-first century has produced a paradox unprecedented in human history: never before has humanity been so hyperconnected, yet never before has it experienced such widespread existential fragmentation. Digital networks collapse geographic distance, algorithmic systems personalize information flows, and virtual environments simulate immersive realities. Yet amid this technological...
Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in treating depression, anxiety, post-traumatic stress disorder, substance use, eating, and personality disorders. Preclinical work shows enhanced neuroplasticity, reduced inflammation, and oxidative stress. Human neuroimaging reveals decreased default...
Background: Patients with psoriasis often experience emotional distress, which may be alleviated through psychological interventions. Objective: To evaluate online Mindfulness-Based Cognitive Therapy (MBCT) as an adjuvant treatment for psoriasis, focusing on severity of lesion, anxiety, depression, quality of life, and itching. Methods: This randomized trial enrolled 109 patients with psoriasis...