MDMA (3,4-methylenedioxymethamphetamine or "Ecstasy") is the fourth-most used illicit substance globally. While previous research found links between MDMA use and mental health outcomes, the direction and nature of this relationship remain unclear. This study assessed whether MDMA use in early adulthood increases the risk of anxiety or depression in mid-30s. A longitudinal, population-based...
Pranayama, yogic breathing techniques, are considered a form of meditation. In classical yoga, the breath is associated with prana; thus, pranayama is a means to control the inner force, the prana shakti or life energy. Pranayama is more than regular breathing and if practiced in structured and methodical manner can reduce the body's physical symptoms of stress and anxiety. It has more recently...
Anxiety can harm behavior, social functioning, and the rehabilitation process, especially in adolescents in conflict with the law. This study aims to analyze the effect of mindfulness meditation therapy on anxiety levels in adolescents in conflict with the law at the Paramita Mataram Center. The study used a quantitative approach with a one-group pre-test post-test pre-experimental design. All...
PsychopharmacologyNovember 28, 2025Elifrances Galdino de Oliveira, Mayara Victória De Souza Barbosa, Diógenes Afonso De Lima et al.
Relevant to the study of neurodevelopmental disorders, maternal immune activation (MIA) models reproduce the high incidence of anxiety disorders and molecular alterations in the cerebellum reported in patients with schizophrenia and autism. In parallel, ketamine, a fast-acting antidepressant, has shown beneficial effects in psychiatric disorders with immune-related components. To investigate...
Treatment with a single dose of a pharmaceutical formulation of lysergic acid diethylamide (LSD) resulted in a dose‐dependent reduction in anxiety in individuals with generalized anxiety disorder (GAD), a Phase 2b study has found. The two highest of four tested dose strengths of the MM120 formulation demonstrated significant improvement relative to placebo.
This research proposes to evaluate Transcendental Meditation (TM) as a complementary integrative practice in the treatment of Anxiety Disorders. Based on WHO data and the Brazilian context, the study highlights the high prevalence of anxiety and the need for therapeutic alternatives beyond the biomedical model. The research, conducted with adults diagnosed in the state of São Paulo, used online...
Objectives: Chronic musculoskeletal pain (CMP) is the leading cause of years lived with disability worldwide and the costliest health condition in the United States. Mindfulness is an effective treatment for CMP, but traditional mindfulness-based interventions (MBIs) are inaccessible for many CMP patients for both format and content reasons. An MBI that leverages music may be a more accessible...
Pharmacological ResearchNovember 22, 2025Zhuo-Ning Zhang, Xin-Yu Hao, Chen Cai et al.5 citations
This randomized, double-blind, parallel-group trial evaluated the efficacy of a single intravenous dose of esketamine (0.3mg/kg) administered at anesthesia induction in reducing postoperative depression and anxiety among patients undergoing cardiac valve surgery. A total of 142 patients from three centers were randomly assigned to receive esketamine or saline. The primary outcomes were the...
Scientia PsychiatricaNovember 19, 2025Ni Wayan Saka Rahayu, Putu Risdianto Eka Putra
Introduction: The pervasive integration of digital media into pediatric life has shifted the clinical focus from screen time quantity to content quality. Emerging "metaphysical" sub-genres, such as algorithmic "Lucid Dreaming" tutorials, pose unique risks to preadolescents. This case report aims to document a novel presentation of acute sleep anxiety precipitated specifically by "Lucid...
Correction: Correction: Effectiveness and satisfaction of mindfulness-based cognitive therapy for children on anxiety, depression, and internet addiction in adolescents: Study protocol for a randomized control trial.