ElifeMarch 27, 2026Målin Schmidt, Anne Hoffrichter, Mahnaz Davoudi et al.3 citations
Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons derived from...
Objective: This study aimed to investigate the intervention effects of cognitive behavioral therapy (CBT) combined with mindfulness training on emotional regulation ability and sleep quality in adolescents with depressive disorders, providing evidence for optimizing non-pharmacological intervention strategies for adolescent depression in clinical settings. Methods: A total of 200 adolescent...
Brain SciencesMarch 26, 2026Piotr Skalski, Katarzyna Pękacka-falkowska, Agnieszka Pluto-Prądzyńska et al.
Background/Objectives: Psilocybin has re-emerged as a promising intervention for neuropsychiatric disorders including major depressive disorder, treatment-resistant depression, anxiety associated with life-threatening illness, obsessive compulsive disorder, and substance use disorders. However, conventional randomized controlled trials (RCTs)-the current gold standard in evidence-based...
Ketamine holds promise for the treatment of post-traumatic stress disorder (PTSD), but challenges remain in delivery and sustained effects. This controlled study evaluates a novel intranasal formulation, employing AmyloLipid nanovesicles (ALN) to enhance ketamine’s therapeutic efficacy in a predator-scent stress (PSS) rat model of PTSD. A total of 130 rats underwent PSS or sham-PSS exposure,...
PsyArXivMarch 25, 2026Sam Malins, Cosmin Manolescu, Tim Sweeney et al.
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Mindfulness-Based Cognitive Therapy is a group psychological therapy that prevents relapse amongst people with recurrent depression. However, many people who attend MBCT do not fully benefit. This study assessed the feasibility, acceptability and initial clinical utility of personalised smart-messaging as an adjunct to remote Mindfulness-Based Cognitive Therapy (rMBCT) for recurrent depression...
March 25, 2026Anna-Marie Ragaller, Lea Teresa Kaubisch, Corinna Reck et al.
preprint
ObjectiveDreams are thought to reflect children's and adolescents' inner psychological processes. Despite their central role in clinical theories, their practical application and empirical grounding vary across psychotherapeutic approaches. This review systematically evaluates empirical evidence on working with dreams in child and adolescent psychotherapy.MethodThe EBSCO (MEDLINE, PsycINFO,...
Scientific ReportsMarch 25, 2026Johannes Björkstrand, Emil Olsson, Oisín Hugh Clancy et al.
Fear-based disorders affect millions worldwide, yet current treatments show limited effectiveness for many patients. While mindfulness is increasingly used clinically for anxiety and trauma disorders, the neural mechanisms underlying its effects on fear processing remain unclear. We conducted a randomized controlled trial using 7T fMRI to test whether mindfulness training enhances fear...
Yoga has strong evidence for reducing stress and anxiety, yet a recent health technology assessment found no significant effect on burnout severity. This article proposes a theoretical explanation for this paradox, arguing that modern Western yoga has been systematically stripped of the meaning-making mechanisms that were historically embedded in traditional practice. Drawing on the history of...
INTRODUCTION: After decades of regulatory marginalization, psychedelic compounds have reemerged as promising therapeutic tools in psychiatry, driven by unmet clinical needs in treatment-resistant mental disorders and by growing evidence of rapid and sustained effects on mood, cognition, and behavior. AREAS COVERED: This narrative review critically examined the current clinical and regulatory...
Neurology BulletinMarch 23, 2026Azat R. Asadullin, Elvina A. Akhmetova, Ilia S. Efremov et al.
BACKGROUND: Substance use disorders remain a global public health problem. In recent decades, the drug market has undergone substantial changes, with traditional drugs increasingly replaced by new psychoactive substances characterized by high toxicity and strong addictive potential. Their distribution via the Internet and social media impedes control and increases risks to public health. AIM:...