This conceptual paper proposes a psychological model exploring how contemplative practices facilitate transformation by influencing ego dissolution, death anxiety, and impulse regulation. Drawing on insights from mindfulness, meditation, and contemplative traditions, the study examines how the temporary reduction of egoic boundaries (ego dissolution) can diminish existential fears and improve...
Introduction: Tinnitus is the perception of sound in the absence of external stimuli, often experienced as ringing or buzzing. While many individuals habituate to tinnitus, others develop chronic tinnitus (CT), which can severely affect emotional well-being. Psychological mechanisms such as anxiety and maladaptive coping are known contributors to tinnitus distress, yet the protective role of...
Background: Cancer patients often experience significant emotional burdens due to the diagnosis, treatment process, and uncertainty regarding their prognosis. Psilocybin, a psychedelic compound found in certain mushroom species, has gained increasing attention in mental health research for its potential therapeutic effects in treating depression and anxiety. Methods: This systematic review...
Letter in reply to Robison R, Barrow R, Conant C, et al. Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial. JAMA. 2025;doi:10.1001/jama.2025.13481 (unpublished, rejected by the journal)
This single-case study examines the impact of a 6-week Mindfulness-Based Intervention (MBI) on an individual experiencing anxiety, with a particular focus on intolerance of uncertainty (IU). A mixed-methods approach was used, combining quantitative measures with qualitative data from session notes, interviews, and participant feedback. Quantitative findings indicated reductions in stress...
This study aims to explore the effectiveness of implementing BAKU (Good and Strong) culture in Islamic mindfulness therapy as an alternative treatment for anxiety and depression among young Muslims, particularly in the Daarut Tauhiid Bandung environment. The background of this study is based on the high prevalence of mental health disorders, such as anxiety and depression, among Indonesian...
One of the most competitive entrance examinations in India is the National Eligibility cum Entrance Test ( NEET ) which puts a lot of academic and psychological pressure on the aspirants. It is common that due to prolonged preparation, repetitive mock test, and high performance expectation among coaching students result in very high test anxiety. This study has explored how mindfulness and test...
Abstract Background and aims Increased connectedness has been proposed as one mechanism through which psychedelics might reduce death anxiety. This study examined whether changes in connectedness—across intrapersonal, interpersonal, and transpersonal domains—were associated with changes in death anxiety following a significant psychedelic experience. Methods A retrospective cross-sectional...
This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. A systematic search identified 8 studies suitable for meta-analysis and 10 additional studies for systematic review. Using a random-effects model, the...
MedicineMarch 6, 2026Hongfei Xiong, Yingxue Xu, Jiayi Liu et al.
This study demonstrates the efficacy of single-dose esketamine regimens, administered orally (ED95: 8.2125 mg/kg; 95% CI: 7.4250-8.4597 mg/kg) and intranasally (ED95: 2.1770 mg/kg; 95% CI: 2.0952-2.1958 mg/kg), in mitigating preoperative anxiety within a pediatric population. These findings highlight the safety and efficacy of esketamine for this patient group.