Debates em PsiquiatriaJune 9, 2026L. Baldaçara, G. A. Rocha, Roberto Mendes Dos Santos et al.
Introduction: Cannabis use and the availability of high-potency cannabis-derived products and synthetic cannabinoids have increased worldwide, contributing to a growing burden of emergency presentations involving intoxication, agitation, psychosis, cardiovascular complications, and other acute toxic effects. Objective: This review aimed to update the clinical approach to emergencies related to...
UPDATED 2026-06-09 Corrected dataset attribution from Timmermann et al. (2019) to Pallavicini et al. (2021) UPDATED 2026-01-21 Background: Psychedelic substances produce profound alterations in conscious experience, yet the neural mechanisms underlying phenomenal richness remain poorly understood. Static measures of neural integration and complexity have shown limited success in predicting...
Scientific ReportsJune 5, 2026Amaury C Mengin, Julie Rolling, Walid Oulehri et al.
Intensive Care Unit (ICU) hospitalizations confront individuals with imminent death and may cause post-traumatic stress disorder (PTSD). In contrast, traumatic events may lead to positive psychological outcomes such as post-traumatic growth. As consciousness is altered, near-death experiences (NDEs) may occur and be associated with post-traumatic growth. Our cross-sectional, monocentric study...
Introduction: Meditation offers a tractable model for probing altered states of consciousness, yet consistent physiological markers remain elusive. This study characterized within-subject autonomic and respiratory modulation across pre-meditation, during-meditation, and post-meditation states in trained Rajyoga practitioners using multiscale heart rate variability (HRV) metrics and...
Recent developments in intracranial EEG allow direct recordings from the human thalamus, offering new insight into thalamocortical relationships in the human brain. In this study, we applied direct intracranial electrical stimulation (iES) to the mid-thalamus, within or close to the mediodorsal nucleus, to examine its impact on conscious experience and causal brain connectivity in 30 patients...
Out-of-body experiences (OBEs) are altered states sometimes accompanied by reports of veridical perception-accurate information seemingly obtained from a vantage point outside the body and ostensibly without conventional sensory input. While case collections and early laboratory studies suggest this possibility, replication under conventional laboratory protocols has been challenging. This...
Abstract Background and Aims Music has been associated with psychedelic experiences throughout human history, from ancient shamanic healing rituals to contemporary psychedelic-assisted therapy (PAT), and is considered integral for positive therapeutic outcomes. Yet optimized protocols and best practice standards for the use of music in PAT are lacking. Methods This interdisciplinary literature...
European PsychiatryJune 1, 2026M. A. Andreo-Vidal, M. Calvo-Valcarcel, Claudia Rodríguez-valbuena et al.
Introduction The differential diagnosis between conversion disorders and psychotic episodes can present a significant clinical challenge. Both conditions may share striking symptoms such as mutism, immobility, altered states of consciousness, and bizarre behavior, which can lead to diagnostic confusion—especially in emergency settings. Objectives This case study aims to analyze the atypical...
Cognitive neurofunctional disorders (NFDs) and dissociative amnesia (DA) are distinct clinical entities, although they may share common pathophysiological mechanisms, vulnerabilities, and risk factors. When carefully assessed, cognitive neurofunctional disorders appear to be relatively common in memory clinics, accounting for up to 20% of consultations. The widespread adoption of the term...
Introduction The role of dissociation in mediating antidepressant response to intranasal esketamine remains debated. While dissociative experiences are often observed during treatment, their predictive value for clinical outcomes is uncertain. Objectives We aimed to assess whether (i) baseline dissociative traits (DES-II) and (ii) early changes in dissociation (ΔDES T0→T2) predict short-term...