The aim of this study is to examine the concept of "immediate experience" in the philosophy of F. H. Bradley, one of the prominent figures of British Idealism, and to re-evaluate the philosophical problems it generates within the context of contemporary philosophy of mind. According to Bradley, immediate experience is a primary, non-relational unity that precedes thought, judgment, and the...
The growing interest, for science and philosophy, in a concept of universal consciousness (cosmopsychism) suggests a re-thinking of theology to give priority to the Spirit as the form of the cosmos. Such a development includes a reassertion of the reality of the self and the other as agents, and of God as approaching us in ‘the humanism of God’.
Classical serotonergic psychedelics primarily exert their profound effects through agonism at the serotonin 2A (5-HT2A) receptor, which is abundantly expressed in many cortical regions, particularly in layer V pyramidal neurons of associative and visual areas. At the cellular level, these receptors are predominantly localized postsynaptically on the soma and apical dendrites. This review...
An expanding body of advanced functional neuroimaging research, particularly using fluorodeoxyglucose (FDG) PET, has sought to characterize the neurologic foundations of consciousness. Investigations have examined a broad spectrum of conscious states, as well as experimental methods for inducing alterations in conscious experience. These states range from typical waking awareness to various...
Positive affect during exercise is a key predictor of continued participation, yet the mechanisms through which mindfulness-based exercise influences affect remain largely inferred from retrospective, outcome-focused designs. This study used a think-aloud (TA) methodology to capture consciously accessible, moment-to-moment experience during exercise and to test whether a single bout of...
Abstract Disorders of consciousness (DoC) are associated with large-scale alterations in brain dynamics, yet the structural factors that constrain these changes remain unclear. Here, we investigate how the topology of the structural connectome shapes the sensitivity of brain dynamics to perturbation using a whole-brain computational model constrained by diffusion MRI-derived connectivity. We...
Psychedelics are a broad category of compounds that induce altered states of consciousness. These drugs have shown remarkable promise for the treatment of debilitating disorders ranging from posttraumatic stress disorder to depression and addiction. Although early studies focused on linking binding targets of psychedelics to their therapeutic effects, these pharmacological and biochemical...
Severe mental illness is frequently approached through nosological criteria focused on symptom severity, neglecting the complexity of lived experience. Phenomenology understands psychopathology not as an isolated biological dysfunction, but as a radical alteration in the structure of being-in-the-world. Grounded in Merleau-Ponty's ontology and Max van Manen's phenomenology of practice, this...
Psychedelic-assisted therapies (PATs) are emerging as novel combination treatments for selected stress- and trauma-related psychiatric conditions, particularly in cases where existing pharmacologic and psychotherapeutic approaches have provided limited benefit. Although current mechanistic models emphasize neuroplasticity, large-scale network changes, and modulation of neurotransmitter systems,...
Over the past two decades, ketamine has emerged as a rapid-acting antidepressant, especially among patients with treatment-resistant depression. As an N-methyl-d-aspartate glutamate receptor antagonist, ketamine has reshaped the understanding of the underlying neurobiological mechanisms of depression treatment. Ketamine induces a transient state of enhanced neuroplasticity and likely...