Journal of Psychopharmacology
February 10, 2021
Carla Pallavicini, Federico Cavanna, Federico Zamberlán et al.
73 citations
BACKGROUND: N,N-dimethyltryptamine is a short-acting psychedelic tryptamine found naturally in many plants and animals. Few studies to date have addressed the neural and psychological effects of N,N-dimethyltryptamine alone, either administered intravenously or inhaled in freebase form, and none have been conducted in natural settings. AIMS: Our primary aim was to study the acute effects of...
PsyCh Journal
February 2021
Sebastian L. Kübel, Henrike Fiedler, Marc Wittmann
A Ganzfeld is a homogenized visual and auditory perceptual field which can induce altered states of consciousness (ASC; Metzger, 1929; Schmidt & Prein, 2019). Using a balanced intrasubject design, we compared participants' experience during two differently colored (red, green) 25-min Ganzfeld sessions with brown noise as acoustic stimulation. Participants were exposed to the colored visual...
Nature Communications
December 22, 2020
Elizabeth D. Ballard, Carlos A. Zarate
10 citations
Ketamine produces immediate antidepressant effects and has inspired research into next-generation treatments. Ketamine also has short term dissociative effects, in which individuals report altered consciousness and perceptions of themselves and their environment. However, whether ketamine's dissociative side effects are necessary for its antidepressant effects remains unclear. This perspective...
ACS Pharmacology & Translational Science
December 10, 2020
David B. Yaden, Roland R. Griffiths
534 citations
Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, certain subjective effects predict therapeutic and other desirable outcomes. Underlying neurobiological mechanisms are likely necessary but not...
Therapeutic Advances in Psychopharmacology
August 14, 2020
Jacob S. Aday, Christopher C. Davoli, Emily K. Bloesch
50 citations
Psychedelic drugs and virtual reality (VR) each have the capacity to disrupt the rigidity and limitations of typical conscious experience. This article delineates the parallels among psychedelic and VR states as well as their potential synergistic applications in clinical and recreational settings. Findings indicate that, individually, psychedelics and VR are used in analogous ways to alter...
bioRxiv Preprint Server
April 4, 2020
Thomas F. Varley, Vanessa Denny, Olaf Sporns et al.
6 citations
preprint
Research has found that the vividness of conscious experience is related to brain dynamics. Despite both being anesthetics, propofol and ketamine produce different subjective states: we explore the different effects of these two anaesthetics on the structure of dynamic attractors reconstructed from electrophysiological activity recorded from cerebral cortex of two macaques. We used two methods:...
Journal of Psychedelic Studies
December 27, 2019
Nathan D. Sepeda, John Clifton, Laura Y. Doyle et al.
23 citations
Background and aims 5-Methoxy- N,N -dimethyltryptamine (5-MeO-DMT) is a potent, short-acting psychedelic that produces strong hallucinogenic effects. The association between the context (i.e., set and setting) of 5-MeO-DMT use and the acute and enduring effects of the substance is unknown. Therefore, this study examined these associations using secondary data from two cross-sectional survey...
Scientific Reports
November 19, 2019
Christopher Timmermann, Leor Roseman, Michael Schartner et al.
325 citations
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7...
European Neuropsychopharmacology
April 2019
Sabine Aust, Matti Gärtner, Laura Basso et al.
About 20 to 30 percent of patients with Major Depressive Disorder (MDD) do not respond to standard treatment and are considered treatment-resistant. The N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant MDD, but it is unknown whether its acute psychological effects are related to the later antidepressant...
Scripta Instituti Donneriani Aboensis
January 16, 2019
Jan Hjärpe
Ta'ziya, "consolation", has become the Shi technical term for the liturgical mourning and commemoration of the martyred Imams, particularly the ritual lamentation for the death of Husayn, celebrated formerly often in the form of passion plays in which the heart is the drama of Kerbela, but in which in addition the whole of human history is viewed sub specie Kerbelae. Nowadays the celebration is...