Nature Medicine
April 1, 2026
Manesh Girn, Manoj K. Doss, Leor Roseman et al.
8 citations
Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented...
bioRxiv Preprint Server
April 4, 2020
Thomas F. Varley, Vanessa Denny, Olaf Sporns et al.
6 citations
preprint
Research has found that the vividness of conscious experience is related to brain dynamics. Despite both being anesthetics, propofol and ketamine produce different subjective states: we explore the different effects of these two anaesthetics on the structure of dynamic attractors reconstructed from electrophysiological activity recorded from cerebral cortex of two macaques. We used two methods:...
bioRxiv Preprint Server
March 27, 2020
Thomas F. Varley, Olaf Sporns, Aina Puce et al.
3 citations
preprint
Whether the brain operates at a critical ‘‘tipping” point is a long standing scientific question, with evidence from both cellular and systems-scale studies suggesting that the brain does sit in, or near, a critical regime. Neuroimaging studies of humans in altered states of consciousness have prompted the suggestion that maintenance of critical dynamics is necessary for the emergence of...
Human Brain Mapping
1995
Karl Friston, Giulio Tononi, Olaf Sporns et al.
114 citations
Abstract This work addresses the complexity of neuronal interactions, the nature of this complexity and how it can be characterised in real neurophysiological processes. A measure of complexity has been introduced recently (Tononi et al. [1994]: Proc Natl Acad Sci USA 91:5033–5037) that is sensitive to the joint constraints imposed by two principles of brain organisation: functional segregation...