Sabine Aust

2 papers in the library · 22 citations · publishing 2019-2022

Papers

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Predicting Antidepressant Effects of Ketamine: the Role of the Pregenual Anterior Cingulate Cortex as a Multimodal Neuroimaging Biomarker

The International Journal of Neuropsychopharmacology August 10, 2022 Anne Weigand, Matti Gärtner, Milan Scheidegger et al. 22 citations

BACKGROUND: Growing evidence underscores the utility of ketamine as an effective and rapid-acting treatment option for major depressive disorder (MDD). However, clinical outcomes vary between patients. Predicting successful response may enable personalized treatment decisions and increase clinical efficacy. METHODS: We here explored the potential of pregenual anterior cingulate cortex (pgACC)...

DOI: 10.1093/ijnp/pyac049 Ketamine Major depressive disorder Anterior cingulate cortex Antidepressant +8

Anxiety during ketamine infusions is associated with negative treatment responses in major depressive disorder.

European Neuropsychopharmacology April 2019 Sabine Aust, Matti Gärtner, Laura Basso et al.

About 20 to 30 percent of patients with Major Depressive Disorder (MDD) do not respond to standard treatment and are considered treatment-resistant. The N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant MDD, but it is unknown whether its acute psychological effects are related to the later antidepressant...

DOI: 10.1016/j.euroneuro.2019.02.005 Full text Anxiety Ketamine Major depressive disorder Treatment-resistant depression +1