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Addiction: all studies

Page 783 of 860: studies 7,821 to 7,830 of 8,594, newest first. Back to the addiction overview

Research

Identification and Status Revisited: The Moderating Role of Self-Enhancement and Self-Transcendence Values

Personality and Social Psychology Bulletin June 1, 2003 Sonia Roccas 92 citations

Two studies examined the moderating role of the importance attributed to self-enhancement and self-transcendence values on the association of group status with identification. In the first study, students reported their personal value priorities, their identification with a group, and their perception of the status of that group. The more importance respondents attributed to self-enhancement...

Plant derivatives in the treatment of alcohol dependency.

Pharmacology, Biochemistry, and Behavior June 1, 2003 Amir H Rezvani, David H Overstreet, Marina Perfumi et al. 95 citations

The present review summarizes the findings of the effects of extracts of purified compounds from several plants on alcohol intake in alcohol-preferring rats. These include St. John's wort (Hypericum perforatum, HPE), kudzu (Pueraria lobata) and ibogaine (Tabernanthe iboga). Alcohol-preferring (P), Marchigian Sardinian (msP), high-alcohol-drinking (HAD), Fawn-Hooded (FH) rats were allowed to...

Persisting visual hallucinations and illusions in previously drug-addicted patients.

Klinische Monatsblatter fur Augenheilkunde March 2003 Marie-Claire Gaillard, François-Xavier Borruat

Tetrahydrocannabinol (cannabis) and lysergic acid diethylamide (LSD) are psychomimetic agents that induce impairment of sensory perception. Illusions and hallucinations are mostly visual. Most frequently the visual phenomena occur in conjunction with drug abuse. Three previously drug-addicted patients were examined for either persisting or spontaneously recurrent visual phenomena. Two patients...

Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration

Brain research. Molecular brain research March 1, 2003 Charles D. Nichols, Efrain E. Garcia, Elaine Sanders‐bush 1 citation

Lysergic acid diethylamide (LSD) is a psychoactive drug that transiently alters human perception, behavior, and mood at extremely low doses. Certain aspects of the behavior elicited by acute doses of LSD closely resemble symptoms of mental disorders such as schizophrenia. Characterizing gene expression profiles after LSD will be important for understanding how it alters behavior, and will lead...

Ketamine Increases Human Motor Cortex Excitability to Transcranial Magnetic Stimulation

The Journal of Physiology March 1, 2003 Vincenzo Di Lazzaro, Antonio Oliviero, Paolo Profice et al. 255 citations

Subanaesthetic doses of the N ‐methyl‐ d ‐aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non‐NMDA transmission through an increase in the release of endogenous glutamate. Little is known about the effects of ketamine on the excitability of the human...

DOI: 10.1113/jphysiol.2002.030486 (opens in new tab) Ketamine Transcranial magnetic stimulation Nmda receptor Glutamatergic +5

Big physics, small doses: the use of AMS and PET in human microdosing of development drugs

Nature Reviews Drug Discovery February 28, 2003 Graham Lappin, R. Colin Garner 257 citations

The process of early clinical drug development has changed little over the past 20 years despite an up to 40% failure rate associated with inappropriate drug metabolism and pharmacokinetics of candidate molecules. A new method of obtaining human metabolism data known as microdosing has been developed which will permit smarter candidate selection by taking investigational drugs into humans...

DOI: 10.1038/nrd1037 (opens in new tab) Investigational drugs Drug discovery Drug development Pharmacology +11

Psychopathological Correlates of Contextualized Images in Dreams

Perceptual and Motor Skills February 1, 2003 Ross Levin, Robert Basile 5 citations

A contextualized image is a powerful central image in a dream which provides a picture context for the dominant emotion of the dreamer. This study examined the psychopathological correlates of both dream and nightmare contextualized images in a community-based sample of 378. As predicted, mean nightmare contextualized image scores were significantly higher than mean dream scores. In addition,...

Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)DOI] in C57BL/6J mice.

Psychopharmacology February 2003 Randy L Smith, Robert J. Barrett, Elaine Sanders‐bush

The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were interested in studying the effects of hallucinogens in genetically modified mice using the...

Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids.

Critical reviews in neurobiology 2003 Laura J Sim-Selley

Marijuana produces a number of characteristic behaviors in humans and animals, including memory impairment, antinociception, and locomotor and psychoactive effects. However, tolerance and dependence to cannabinoids develops after chronic use, as demonstrated both clinically and in animal models. The potential therapeutic benefits of certain cannabinoid-mediated effects, as well as the use of...

An Impact of Conscious Connected Breathing on Emotional States

Zenodo (CERN European Organization for Nuclear Research) 2003 Heyda Alicja preprint

The Impact Of Conscious Connected Breathing Training On Emotions Alicja Heyda, The Healing Breath Journal – a Journal of Breathwork Practice, Spirituality and Psychotherapy, vol.5, no 2 p. 9-18 Abstract The goal of C.C.B. (rebirthing) is to unblock breathing, gently relax chronic muscle tensions, and liberate repressed emotions and memories hidden behind. During the C.C.B. session, memories...