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Addiction: all studies

Page 769 of 857: studies 7,681 to 7,690 of 8,563, newest first. Back to the addiction overview

Research

Role of α2A‐adrenoceptors in the effects of MDMA on body temperature in the mouse

British Journal of Pharmacology July 18, 2005 Sotiria Bexis, James R. Docherty 43 citations

3,4‐Methylenedioxymetamphetamine (MDMA) produces complex effects on body temperature, including hypo‐ and hyperthermic components that vary with ambient temperature and strain of rat. We have previously reported that MDMA is an α 2 ‐adrenoceptor agonist, and α 2 ‐adrenoceptor agonists such as clonidine produce hypothermia. The purpose of this study was to investigate the effects of MDMA on core...

DOI: 10.1038/sj.bjp.0706320 (opens in new tab) MDMA Hypothermia Hyperthermia Clonidine +4

Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.

European Journal of Pharmacology July 11, 2005 Kinzo Matsumoto, Ryo Morishige, Yukihisa Murakami et al.

Isorhynchophylline is a major oxindole alkaloid found in Uncaria species which have long been used in traditional Chinese medicine. Here, we investigated the effects of isorhynchophylline and isorhynchophylline-related alkaloids on 5-hydroxytryptamine (5-HT) receptor-mediated behavioural responses in mice and 5-HT-evoked current responses in Xenopus oocytes expressing 5-HT2A or 5-HT2C...

6 Scholars Lock Horns

July 7, 2005 Paul Marshall

Abstract This chapter classifies mystical epistemologies into five types (direct contact, post-Kantian, mediatory, radical contextualist, naturalistic), and examines two competing perspectives on mystical experience. On the one hand, radical contextualists such as Bruce Garside and Steven Katz have claimed that mystical experience is largely a product of indoctrination and enculturation and is...

Age-dependent (+)MDMA-mediated Neurotoxicity in Mice

Neurotoxicology July 6, 2005 María E. Reverón, Terrence J. Monks, Christine L. Duvauchelle 24 citations

In the present study the effects of a neurotoxic regimen of (+)-MDMA (20 mg/kgx4, s.c.) in 4- and 10-week-old C57Bl/6J mice during treatment and 7 days post-treatment were examined. Rectal temperatures monitored between (+)-MDMA injections (30 min post-injection/2 h intervals) revealed hyperthermic responses in both age groups, with the magnitude of the response significantly greater in older...

Mindfulness and acceptance: expanding the cognitive-behavioral tradition

Choice Reviews Online July 1, 2005 Hayes, Steven C. 1948- 1,291 citations

1. Acceptance and Commitment Therapy and the New Behavior Therapies: Mindfulness, Acceptance, and Relationship, Steven C. Hayes2. Dialectical Behavior Therapy: Synthesizing Radical Acceptance with Skillful Means, Clive J. Robins, Henry Schmidt III, and Marsha M. Linehan3. Mindfulness-Based Cognitive Therapy: Theoretical Rationale and Empirical Status, Zindel V. Segal, John D. Teasdale, and J....

MDMA affects both error-rate dependent and independent aspects of decision-making in a two-choice prediction task

Journal of Psychopharmacology June 27, 2005 Franz X. Vollenweider, Matthias E. Liechti, Martin P. Paulus 24 citations

Decision-making, i.e. selecting an action from a number of alternatives when the outcome is uncertain, is a complex process that is important for everyday life. 3,4-Methylenedioxymethamphetamine (MDMA), also known as 'Ecstasy', is a widely used recreational drug that is known to increase serotonin (5-HT) and, to a lesser extent, dopamine (DA) in animals. This study examined whether MDMA alters...

The phenomenon of self-sufficiency of the mystical-aesthetic experience: a place in the religious-mystical and scientific worldviews of the XX-XXI centuries

Ukrainian Religious Studies June 14, 2005 Mykhailo G. Murashkin

The formulation of the problem is that neither religious nor scientific, or worldview, appear in real life as something self-sufficient. They depend on each other. Analysis of recent research on this issue assumes self-sufficiency as a subjective

Neural substrates of faulty decision-making in abstinent marijuana users.

Neuroimage June 2005 Karen I Bolla, Dana A Eldreth, John A Matochik et al.

Persistent dose-related cognitive decrements have been reported in 28-day abstinent heavy marijuana (MJ) users. However, the neural substrates of these decrements in cognitive performance are not known. This study aimed to determine if 25-day abstinent MJ users show persistent dose-related alterations in performance and brain activity using PET H(2)(15)O during the Iowa Gambling Task-IGT (a...

Impact of regular meditation practice on EEG activity at rest and during evoked negative emotions.

International Journal of Neuroscience June 2005 Ljubomir Aftanas, Semen Golosheykin

The main objective of the present investigation was to examine how long-term meditation practice is manifested in EEG activity under conditions of non-emotional arousal (eyes-closed and eyes-open periods, viewing emotionally neutral movie clip) and while experiencing experimentally induced negative emotions (viewing aversive movie clip). The 62-channel EEG was recorded in age-matched control...

The validity of DSM-IV dissociative disorders categories in south-west Uganda.

Transcultural Psychiatry June 1, 2005 Marjolein Van Duijl, Etzel Cardeña, Joop De Jong 62 citations

There is little systematic research on the cross-cultural validity of the dissociative disorders, especially in non-western countries. This study evaluates the fit of the DSM-IV classification and concepts of these disorders with local concepts, experiences and local presentations in south-west Uganda. We conducted focus group discussions with medical students, traditional healers, religious...