Background and purpose: We have investigated the ability of the β 3 ‐adrenoceptor antagonist 1‐(2‐ethylphenoxy)‐3‐[[(1S)‐1,2,3,4,‐tetrahydro‐1‐naphthalenyl]amino]‐(2S)‐2‐propanol hydrochloride (SR59230A) to affect the hyperthermia produced by methylenedioxymethamphetamine (MDMA) in conscious mice and whether α 1 ‐adrenoceptor antagonist actions are involved. Experimental approach: Mice were...
The effects of injection of 3,4‐methylenedioxymethamphetamine (MDMA), 3,4‐methylenedioxyamphetamine (MDA) and N ‐ethyl‐3,4‐methylenedioxyamphetamine (MDEA) (all 20 mg kg −1 ) on blood pressure, heart rate, core body temperature and locomotor activity in conscious rats were investigated using radiotelemetry. MDMA and MDA produced a prolonged increase in both systolic and diastolic pressures,...
3,4‐Methylenedioxymetamphetamine (MDMA) produces complex effects on body temperature, including hypo‐ and hyperthermic components that vary with ambient temperature and strain of rat. We have previously reported that MDMA is an α 2 ‐adrenoceptor agonist, and α 2 ‐adrenoceptor agonists such as clonidine produce hypothermia. The purpose of this study was to investigate the effects of MDMA on core...