Addiction
July 31, 2017
Christine L. Miller
2 citations
The review of cannabis-induced psychosis by Ian Hamilton in Addiction 1 raised key issues that warrant further exploration. In focusing upon the literature up to the turn of the 21st century, the author omitted the subsequent explosion of scientific inquiry into a causal relationship between cannabis use and chronic psychotic disorders. The author pointed towards one type of relevant research,...
Journal of MCU Peace Studies
July 30, 2017
Sorawit Wongsaard
This research found that the concept of perception in Theravada Buddhist Philosophy, which is a perception that one employs in approaching one’s externality and internality that came into contact that is categorized in three main areas, namely external objects, internal organs, and the mind or consciousness; these three are the areas in which perception is based upon. These are the tools of...
Anesthesiology
July 30, 2017
Kelly Jonkman, Andreas Duma, Erik Olofsen et al.
56 citations
BACKGROUND: Esketamine is traditionally administered via intravenous or intramuscular routes. In this study we developed a pharmacokinetic model of inhalation of nebulized esketamine with special emphasis on pulmonary absorption and bioavailability. METHODS: Three increasing doses of inhaled esketamine (dose escalation from 25 to 100 mg) were applied followed by a single intravenous dose (20...
Journal of Natural Products
July 28, 2017
Anil Yilmaz, Rachel Saylor Crowley, Alexander M. Sherwood et al.
Columbin (1) is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species. These species generally grow in Asia and Africa and have been used in folk medicine for their apparent analgesic and antipyretic activities. Columbin (1) is of particular interest due to its structural similarity to the known kappa-opioid receptor (KOR) agonist salvinorin A. Given that the KOR...
Frontiers in Behavioral Neuroscience
July 28, 2017
Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro‐da‐silva et al.
38 citations
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich in N, N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors, with properties similar to those of serotonin. Despite substantial progress in the development of new drugs to treat anxiety and depression, current...
Psychopharmacology
July 24, 2017
Matthew B Young, Seth D. Norrholm, Lara M. Khoury et al.
103 citations
We validate enhancement of fear memory extinction by MDMA in a translational behavioral model, and reveal the importance of 5-HTT and 5-HT2A receptors to this effect. These observations support future clinical research of MDMA as an adjunct to exposure therapy, and provide important pharmacological considerations for clinical use in a population frequently treated with 5-HTT inhibitors.
Addiction
July 22, 2017
Madeline H. Meier, Avshalom Caspi, Andrea Danese et al.
129 citations
AIMS: This study tested whether adolescents who used cannabis or met criteria for cannabis dependence showed neuropsychological impairment prior to cannabis initiation and neuropsychological decline from before to after cannabis initiation. DESIGN: A longitudinal co-twin control study. SETTING AND PARTICIPANTS: Participants were 1989 twins from the Environmental Risk (E-Risk) Longitudinal Twin...
bioRxiv Preprint Server
July 21, 2017
Mehrak Javadi-Paydar, Jacques D. Nguyen, Sophia A. Vandewater et al.
7 citations
preprint
The broad diversity of synthetic cathinone psychostimulant drugs that are available to users complicates research efforts to provide understanding of health risks. Second generation cathinones pentedrone and pentylone are distinguished from each other by the 3,4-methylenedioxy structural motif (which distinguishes methamphetamine from 3,4-methylenedioxymethamphetamine) and each incorporates the...
Drugs and Alcohol Today
July 20, 2017
Mark E. Shevlin, Eoin McElroy, Jamie Murphy et al.
8 citations
Purpose While research has consistently identified an association between cannabis use and psychosis, few studies have examined this relationship in a polydrug context (i.e. combining cannabis with other illicit substances). The paper aims to discuss this issue. Design/methodology/approach The present study sought to examine the association between recreational drug use (cannabis only vs...
Oxford Scholarship Online
July 20, 2017
The essays in this volume explore those aspects of Kant’s writings which concern issues in the philosophy of mind. These issues are central to any understanding of Kant’s Critical philosophy and they bear upon contemporary discussions in the philosophy of mind. Fourteen specially written essays address such questions as: What role does mental processing play in Kant’s account of intuition? In...