Space and Culture, India
September 26, 2021
K. Koirala, Bidya Nath Koirala, Gem Prasad Gurung
3 citations
This paper focuses on the epistemological understanding of finding the science embedded within Shad darsana and Buddhist philosophy. The primary rationale of this study is to dig out the scientific notion that consists of Shad darsana and Buddhist philosophy. Shad darsana or six systems of Hindu philosophy considered as the orthodox/astika philosophy and accept the authority of Vedas, which...
Journal of Affective Disorders Reports
September 22, 2021
David E. Gard, Mollie Pleet, Ellen Bradley et al.
33 citations
Growing evidence suggests that psilocybin, the active ingredient in hallucinogenic mushrooms, can rapidly and durably improve symptoms of depression, leading to recent breakthrough status designation by the FDA and legalization for mental health treatment in some jurisdictions. Depression in bipolar disorder is associated with significant morbidity and has few effective treatments. However,...
bioRxiv Preprint Server
September 20, 2021
Laura M Hack, Katherine G. Warthen, Xue Zhang et al.
2 citations
preprint
Ketamine is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor that is both a drug of abuse and an FDA-approved anesthetic used off-label for treatment-resistant depression. Despite its growing clinical use for depression and pain, the relationships between the acute dissociative and affective effects of ketamine that contribute to its abuse liability and...
Journal of Analytical Toxicology
September 17, 2021
Elba Arango, Allison Toriello, Zoila Rosario et al.
17 citations
Ketamine is a dissociative anesthetic used in veterinary and human medicine since the 1970s. Its clinical use has expanded to control of seizures, by pre-hospital emergency medical services (EMS), and is finding new purpose as an analgesic alternative and antidepressant. Ketamine brings hope for effective management of chronic pain in the absence of opioids and decreasing suicidal ideations;...
European Psychologist
September 17, 2021
Matthias Forstmann, Christina Sagioglou
6 citations
Abstract. After decades of stagnation, research on psychedelic substances (such as lysergic acid diethylamide [LSD], psilocybin, or N,N-dimethyltryptamine [DMT]) has experienced a renaissance over the last 10 years, with various major research programs being conducted across Europe and the United States. This research primarily investigates the potential of psychedelics in the treatment of...
Neuropsychologia
September 17, 2021
Elizabeth Schechter, Tim Bayne
11 citations
In a recent series of experiments, Pinto and colleagues found that the split-brain patient D.D.C. was able to respond accurately to stimuli in either visual field, whether using his right hand, his left hand, or verbally. Pinto and colleagues argue that this demonstrates that a split-brain patient remains a unitary agent and thus continues to possess a unified consciousness. This paper provides...
Clocks & Sleep
September 16, 2021
Rabya Mughal, Siu Sing Wong, Dagmara Dimitriou et al.
8 citations
Children with Foetal Alcohol Spectrum Disorders (FASD) and Autism Spectrum Disorders (ASD) experience significantly higher rates of sleep disturbances than their typically developing (TD) peers. Pre-sleep anxiety and waking emotional content is known to affect the content and frequency of nightmares, which can be distressing to children and caregivers. This is the first study to analyse...
Bulletin of Integrative Psychiatry
September 15, 2021
Dan Cătălin Oprea, Loretta Epure, Vasile Chiriță et al.
Psychedelic drugs (also called hallucinogens, psychotogenics, psycholytics, entheogens) are substances that act mainly on the 5-HT2 serotonergic receptor.There are two main groups of psychedelics: indoleamines (lysergic acid diethylamide-LSD, N, N-dimethyltryptamine-DMT, and psilocybin) and phenethylamines (mescaline, dimethoxymethamphetamine-DOM, methylenedioxyamphetamine-MDA, and...
Journal of Neurochemistry
September 14, 2021
Urszula Kozłowska, Charles D. Nichols, Kalina Wiatr et al.
78 citations
Abstract The studies of psychedelics, especially psychedelic tryptamines like psilocybin, are rapidly gaining interest in neuroscience research. Much of this interest stems from recent clinical studies demonstrating that they have a unique ability to improve the debilitating symptoms of major depressive disorder (MDD) long‐term after only a single treatment. Indeed, the Food and Drug...
Scientific Reports
September 13, 2021
Xin-ping Ouyang, Zhengjia Wang, Mei Luo et al.
To investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT) expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino]-2-Deoxyglucose (2-NBDG) was added to the cells to test the effects of ketamine on glucose uptake, production of lactate, and expression levels of GLUT, ERK1/2, AKT, and AMPK....