Exploration of Neuroscience
September 24, 2024
Bushra Yasin, Shivani Mehta, George Tewfik et al.
2 citations
Chronic neuropathic pain is a significant public health issue affecting an estimated 1.5 billion individuals worldwide. The mechanisms underlying chronic pain are multifaceted and not fully understood. Chronic pain amplifies specific neural pathways through peripheral and central sensitization triggered by repeated exposure to noxious stimuli, ultimately resulting in physical and emotional...
ACS Omega
September 24, 2024
Ana Y Martínez, Alexis Caballero, Rodrigo Ramírez et al.
Psychedelics are psychoactive substances that produce changes in thoughts and feelings and modifications in perceptions of reality. The most potent psychedelic is also the first semisynthetic hallucinogen (lysergic acid diethylamide). Psychedelics have been investigated for decades because of their potential therapeutic effects in the treatment of neuropsychiatric diseases and also because...
Cortica
September 21, 2024
Maya Oberson
Dans ce travail, l’objectif principal est d’explorer les effets et l’efficacité du diéthylamide de l'acide lysergique, plus communément connu sous le nom de LSD, dans le traitement du trouble lié à l’usage de l’alcool. Une recherche systématique, s’appuyant sur différentes bases de données, a été menée dans le but de sélectionner des articles traitant de la problématique en...
Nature Communications
September 20, 2024
Václav Havel, Andrew C Kruegel, Benjamin Bechand et al.
18 citations
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and a highly complex molecular mechanism. We introduce a class of iboga alkaloids - termed oxa-iboga - defined as benzofuran-containing iboga analogs and...
September 19, 2024
Philip Gerrans
Abstract The self is an avatar, a virtual entity, constructed by the brain to play the game of life. To control the organism the mind manipulates the avatar through the world. The avatar co-ordinates bodily, perceptual, sensorimotor, cognitive, and metacognitive processes in pursuit of the organism’s goals, the most basic of which is homeostatic maintenance. Other processes are layered over...
Communications Biology
September 19, 2024
Iván Mindlin, Rubén Herzog, Laouen Belloli et al.
18 citations
Disorders of consciousness (DoC) represent a challenging and complex group of neurological conditions characterised by profound disturbances in consciousness. The current range of treatments for DoC is limited. This has sparked growing interest in developing new treatments, including the use of psychedelic drugs. Nevertheless, clinical investigations and the mechanisms behind them are...
Journal of Psychiatry and Neuroscience
September 19, 2024
Gabriella Gobbi
7 citations
For 3000 years, psychedelics have been used in religious contexts to enhance spiritual thinking, well-being, and a sense of community. In the last few years, a renaissance in the use of psychedelic drugs for mental disorders has occurred in Western society; consequently, a pressing scientific need to elucidate the intricate mechanisms underlying their actions has arisen. Psychedelics mainly...
Journal of Pharmacology and Experimental Therapeutics
September 18, 2024
Candace B Johnson, Donna Walther, Matthew J. Baggott et al.
5 citations
3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in nonmedical contexts that pose risk for cardiovascular and neurologic complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines 5-hydroxytryptamine (5-HT),...
Journal of Complementary Medicine & Alternative Healthcare
September 17, 2024
Dírcea Rodrigues
Title: Use of psilocybin in the treatment of mental disorders: systematic review of clinical trials. Objective: To evaluate the high-impact evidence on the neurobiology, efficacy, safety, and feasibility of using psilocybin in the treatment of mental disorders such as depression, anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), smoking, and alcoholism
Alcoholism & Drug Abuse Weekly
September 16, 2024
Alison Knopf
The typical conundrum with cannabis use by adolescents and first episode psychosis — which came first? — was displaced by Steven Batki, M.D. in a plenary session at the Cape Cod Symposium on Addictive Disorders (CCSAD) last week. Bakti, who is professor of psychiatry at the University of California San Francisco Weill Institute for Neurosciences, presented his conclusions allowing the audience...