bioRxiv Preprint Server
April 12, 2025
Alina T. He, Wenbo Zhang, Hongbin Li et al.
preprint
Ketamine has emerged as a rapid-acting and robust antidepressant1,2. However, the mechanism of its antidepressant action remains enigmatic. The core issue that has yet to be resolved is whether NMDA receptors (NMDARs), which are subject to open channel blockade by ketamine3,4, mediate the antidepressant effect. NMDARs naturally undergo alternative splicing of the obligatory GluN1 subunit5,...
Journal of Neural Engineering
April 11, 2025
Rick Evertz, Andria Pelentritou, John Cormack et al.
Objective. Resting electroencephalographic activity is typically indistinguishable from a filtered linear random process across a diverse range of behavioural and pharmacological states, suggesting that the power spectral density of the resting electroencephalogram (EEG) can be modelled as the superposition of multiple, stochastically driven and independent, alpha band (8-13 Hz) relaxation...
Psychopharmacology
April 11, 2025
Swanti Gupta, Raj K Bhatnagar, Dinesh Gupta et al.
27 citations
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanisms underlying its powerful psychedelic effects and out-of-body experiences continue to intrigue scientists. The functional role of DMT remains ambiguous. This paper explores the endogenous presence of DMT in the human body and its diverse neuroregulatory functions, which...
Psychoactives
April 10, 2025
Lumír Ondřej Hanuš, А. О. Шпаков
The history of cannabis research spans centuries, with a focus on isolating and understanding its active compounds. Although plants like opium and coca yielded active alkaloids relatively early, cannabis posed unique challenges due to its active substances existing in oily mixtures that were difficult to isolate. Early studies in the 19th century, such as Ferdinand Tscheppe’s 1821 research,...
Education Economics
April 10, 2025
Christina Peters, Katherine M. Sauer
ABSTRACT We conducted a randomized experiment in an academic setting to test two research questions: first, does participating in guided meditations improve student performance? Second, does mindfulness meditation reduce reliance on mental heuristics? Our results document that students who are asked to complete brief meditations immediately before exams perform better compared to students in a...
ACS Medicinal Chemistry Letters
April 10, 2025
Robert B. Kargbo
Psychedelics and AI modulate cognitive frameworks, disrupt rigid thought patterns, and enhance neuroplasticity, offering therapeutic potential for depression, PTSD, and addiction. Relaxing neural filters reveal altered states of consciousness, challenging perceptions of reality. This Viewpoint explores their neurobiological mechanisms and AI's role in augmenting psychiatric treatments.
Biology direct
April 10, 2025
Matteo Ardini, Francesco Angelucci, Francesca Rea et al.
The "psychedelic renaissance" is sparking growing interest in clinical research, along with a rise in clinical trials. Substances such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin and N,N-dimethyltryptamine (DMT) are involved. The focus of this paper is on indolethylamine N-methyltransferase (INMT), a crucial enzyme in the biosynthesis of key compounds, including DMT, which meets...
Journal of Humanistic Psychology
April 9, 2025
Danielle Leonard, Thomas R. Brooks
1 citation
Peak and mystical experiences can be seen as states of consciousness that exist on a spectrum of varying intensity and duration. They are often described as moments of profound joy, ecstasy, and awe that involve feelings of noetic quality, decreased self-salience, and heightened interconnectedness. The renewed interest in psychedelics as a potential tool for therapeutic intervention has been...
Journal of Neuroscience
April 9, 2025
Audrey Dureux, Alessandro Zanini, Azadeh Jafari et al.
3 citations
Auditory deficits are a well-known symptom in neuropsychiatric disorders such as schizophrenia. The noncompetitive N-methyl-d-aspartate receptor antagonist ketamine has been used to model sensory and cognitive deficits in nonhuman primates, but its whole-brain effects remain largely unknown. Here we employed ultra-high field functional magnetic resonance imaging at 9.4 T in awake male and...
Pharmaceuticals
April 9, 2025
Hossein Omidian, Alborz Omidian
11 citations
Psilocybin, a naturally occurring psychedelic compound, has garnered renewed scientific interest for its potential in treating psychiatric and neurological disorders. This review systematically examines the latest research on psilocybin’s pharmacokinetics, pharmacodynamics, clinical efficacy, and safety profile. Emerging evidence supports its efficacy in conditions such as major depressive...