A COMPUTABLE SOLUTION TO THE NP-HARD PROBLEM AT THE HEART OF INTEGRATED INFORMATION THEORY. Tononi's IIT offers a mathematically principled measure of consciousness — Phi — but exact computation is NP-hard, and the Gaussian approximation breaks down on modern sparse neural networks. This paper cracks the problem open. We derive a computable integrated information functional — chi-square Phi —...
This article considers the phenomenon of meta-messages as a central mechanism of the psychofunctional unblocking method (PF_R) and analyzes its putative neurobiological and psychophysiological foundations. The aim of the study was to determine the role of meta-messages in the activation of unconscious processes associated with the resolution of internal conflicts, emotional processing, and...
We examined the in vivo effects of the hallucinogen 4-iodo-2,5-dimethoxyamphetamine (DOI). DOI suppressed the firing rate of 7 of 12 dorsal raphe (DR) serotonergic (5-HT) neurons and partially inhibited the rest (ED(50) = 20 microg/kg, i.v.), an effect reversed by M100907 (5-HT(2A) antagonist) and picrotoxinin (GABA(A) antagonist). DOI (1 mg/kg, s.c.) reduced the 5-HT release in medial...