The Abhidhamma, a classical Buddhist doctrine, offers a profound understanding of cognitive processing and sensory perception, concepts formulated over 2700 years ago and recently reflected in modern neuroscience. It presents a sophisticated cognitive model in which consciousness (citta), mental factors (cetasika), and materiality (rūpa) co-arise and function in a causally interdependent...
Optimizing organic fertilizer recommendations can be cost-effective and affordable for resource-poor farmers by increasing crop yield and income. This field experiment was conducted to determine the most effective vermicompost application method for enhancing maize production in the Laelay Adiyabo district (Chiraro, Gudelo, and Hibret experimental sites) of Tigray, Ethiopia, during the 2019...
Mental health problems that can appear in women during pregnancy include fear, anxiety, feelings of vulnerability, stress, and depression. Mindfulness (MF) is a specific meditation technique that can help during treatment for prenatal mood disorders, emotional distress, and psychological strains. The aim of this study is to determine the effectiveness of a specific meditation approach in women...
Current BiologyJune 9, 2025Davide Albertini, Maria Del Vecchio, Ivana Sartori et al.9 citations
Distilling the neural correlates of consciousness (NCCs) in humans is challenging due to limitations in the spatiotemporal resolution of recording techniques and confounds related to pre- and post-perceptual processes. In this study, we leveraged the detailed insights provided by human intracortical recordings to elucidate how somatosensory responses to simple tactile stimuli vary across...
Abstract Background Opioid abstinence induces persistent emotional disturbances and widespread neuroplastic changes, in areas of the brain including the hippocampus. Although ketamine and its metabolite ( 2R,6R )-hydroxynorketamine (HNK) show potential in reversing opioid abstinence-related deficits in rodents, the molecular mechanisms underlying their efficacy remain poorly understood. Methods...
Neurotoxicity ResearchJune 7, 2025Felype Valentim Duarte Castelhano, Carolina Aparecida de Faria Almeida, Giulia de Assis Braz et al.3 citations
Ketamine is an anesthetic drug that has been illegally used due to its hallucinogenic effects. Its use is often concomitant with drugs such as ethanol, which can cause irreversible damage to the central nervous system. This study investigates the neurotoxicity of ketamine-ethanol combination in human neuroblastoma SH-SY5Y cell line, exploring the mechanisms preceding cell death. Cell viability,...
Treatment-resistant depression (TRD) remains a challenge, with many patients unresponsive to standard antidepressants. NN-dimethyltryptamine (DMT), a fast-acting psychedelic, offers potential benefits due to its rapid onset and short duration. This review, registered with the Open Science Framework (DOI: 10.17605/OSF.IO/6D9WC), summarizes the safety and tolerability of DMT in early-phase...
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carry personal meaning. While research has demonstrated the capacity for these compounds to promote psychological wellbeing, it has yet to be shown to what extent they modulate "meaning in life", a specific contributor to mental and physical health....
However, Yoga is widely regarded as a very old mind body practice with the potential to lead to mental health and wellbeing. In this study, the supplement of Yoga to pharmacotherapy in the management of mental health disorders was investigated. Although no pharmacological interventions still remain the bedrock of treatment for disease such as depression, anxiety or stress related, Yoga has a...
Abstract Background Cannabis is one of the most widely used psychoactive substances in the world and is increasingly investigated as a treatment for neuropsychiatric conditions. Cannabis contains delta-9-tetrahydrocannabinol (THC), which is thought to underlie its main psychoactive effects, and cannabidiol (CBD), which has been proposed to modulate the effects of THC on the brain. Both have...