Ketamine, originally synthesized in 1962, has gained increasing attention due to its rapid and sustained antidepressant effects in treatment-resistant depression (TRD). Unlike traditional antidepressants, ketamine acts on multiple neurotransmitter systems, including NMDA receptor antagonism and AMPA receptor potentiation, offering a novel mechanism for mood regulation. Beyond psychiatry,...
This study aims to examine the effectiveness of the Mindful Podcast program in reducing loneliness among university students identified as experiencing mobile phone addiction. Using a quasi-experimental one-group pretest–posttest design, the intervention involved 10 participants who were selected through a screening process using the Mobile Phone Addiction Index (MPAI) and the R-UCLA Loneliness...
Objective of the study is a philosophical and methodological analysis of the phenomenon of the actual possibility of self-consciousness emergence in artificial intelligence. Methodological basis of the study. The authors use a transdisciplinary approach that makes it possible to identify an invariant in the spectrum of cognitive practices that confirms the “weak” version of artificial...
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder marked by motor symptoms due to dopaminergic degeneration and non-motor symptoms such as depression, anxiety, and cognitive impairment, which significantly affect patients' quality of life. Traditional dopaminergic therapies address motor symptoms but offer limited efficacy for neuropsychiatric manifestations. Psilocybin, a...
Trauma-related disorders and substance use are disproportionately underdiagnosed and undertreated in individuals with High-Functioning Autism (Level 1 Autism Spectrum Disorder), particularly those in underserved or marginalized communities. Emerging evidence suggests that psychedelic-assisted therapies—including psilocybin, MDMA, and ketamine—offer promising outcomes in the treatment of...
This study aimed to validate and culturally adapt the Altered States of Consciousness Rating Scale (OAV) and Five Dimensional-Altered States of Consciousness Questionnaire (5D-ASC) for Brazilian Portuguese to measure altered states of consciousness in the context of psychedelic research. A parallel back-translation model was employed with expert reviews to ensure linguistic and cultural...
Siinses artiklis arutlen kahe küsimuse üle: kui õppija kasutab akadeemilise teksti kirjutamisel tekstiroboti abi, siis (1) kuidas võiks mõista tekstiroboti rolli selles protsessis ning (2) kui akadeemilise teksti kirjutamist käsitleda laiendatud kognitiivse protsessina, siis kas tekstirobot laiendab inimvaimu? Artiklis tekstiroboti võimalikke rolle kaaludes selgub, et tekstirobotit ei saa...
The present study explored the behavioral stressing action of a 15-min forced swim test (FST) session, changes in CA3-medial prefrontal cortex (mPFC) connection responsivity, and whether ketamine reverses such changes. Two groups of male Wistar rats were subjected to a 15-min FST session. Sixty minutes later, they were injected with either saline (stress [STR] SAL group) or ketamine (STR KET...
Although transarterial chemoembolization (TACE) is an effective treatment for liver cancer, clinical practice has shown that many patients experience significant psychological distress following the procedure, which can hinder postoperative recovery and prognosis. Therefore, effective and evidence-based interventions are urgently needed to address this issue. To evaluate the impact of nursing...
Psychedelics are increasingly used in the general population, yet they are associated with increased risk of psychosis in a minority of users that can experience psychedelic-induced psychosis (<1 % in controlled trial settings). In contrast, the evidence regarding the treatment of psychedelics-induced psychosis remains to date scarce. We conducted a PRISMA 2020-compliant systematic review...