Posttraumatic stress disorder (PTSD) is characterized by difficulties in emotion regulation and altered recruitment of prefrontal control systems during cognitive reappraisal. Cannabinoid signaling has been implicated in stress and affect regulation, yet dose-dependent effects of acute delta-9-tetrahydrocannabinol (THC) on the neural mechanisms supporting reappraisal in PTSD remain unclear. In...
Since the discovery of the first antipsychotic, pharmacological treatment of schizophrenia (SCZ) has primarily relied on dopamine D2 receptor antagonist. However, variability in treatment responses highlights the need for novel biomarkers and therapeutics targets. Here, we developed a dual-hit mouse model combining maternal immune activation (MIA) induced by polyinosinic-polycytidylic acid...
Serotonergic psychedelics have attracted considerable interest as promising therapeutic agents. However, the molecular mechanisms linking their acute hallucinogenic-like effects to longer-lasting neuroplastic responses remain incompletely understood, partly because of the scarcity of native neural models suitable for mechanistic studies. Here, we developed a neural stem cell-derived in vitro...
CannabisJuly 15, 2026Saara Greene, Allyson Ion, Rochelle Maurice et al.
Objective: This paper presents rich and in-depth insights emerging from "Wading through the Weeds" (WttW), a participatory arts-based research study that used the Photovoice method to centre the lived experience of 23 mothers throughout Canada who consumed cannabis during pregnancy, lactation and motherhood. Method: Specifically, this paper examines and elucidates the ways that the mothers in...
In an increasingly digitized world, spirituality is no longer confined to physical gatherings. Virtual liturgies, prayer apps, online communities, and digital retreats now offer unprecedented accessibility and resonance. These platforms can extend sacred space and sustain connection, yet they also risk enclosing believers within curated environments that privilege immediacy, emotional...
Risiko Perilaku Kekerasan (RPK) merupakan masalah serius dalam keperawatan jiwa yang memerlukan kontrol emosi yang cepat. Teknik mindfulness metode STOP (Stop, Take a breath, Observe, Proceed) merupakan pendekatan kognitif untuk meningkatkan kesadaran diri pasien dalam mengelola kemarahan. Namun, efektivitasnya dapat bervariasi tergantung pada etiologi RPK, baik sebagai masalah utama (core...
MetricsJuly 15, 2026Richard J. DiRocco, Sonia F. Pearson, Edgar E. Coons
We present a unifying thesis which posits that the biological resolution of uncertainty is a fundamental adaptation to entropy’s negative impact on the highly ordered molecular structures required to maintain the living state. These molecular biological adaptations are highly conserved and play a critical role in the survival of the earliest multicellular organisms and the vertebrates...
Psychedelics such as psilocybin have been linked to enhanced neuroplasticity and symptom relief in affective disorders, but the neurobiological mechanisms and impact of environmental context remain unclear. Here, we tested whether a single dose of psilocybin (0.3 mg/kg) alters synaptic density in healthy individuals and whether setting-dependent subjective experience shapes this effect. Fifteen...
Classic psychedelics, including psilocybin, LSD, DMT, 5-MeO-DMT, mescaline, and phenethylamines such as DOI, exert their core effects through 5-HT2A receptor agonism, inducing widespread neurobiological and behavioral changes relevant to psychiatric research. Emerging evidence suggests that these effects are modulated by sex, yet this dimension remains underrepresented in studies. This review...
Dissociative psychoactive substances (such as ketamine and PCP) present a challenge to standard models of altered states of consciousness. Unlike classical hallucinogens which enrich or distort conscious content, dissociatives induce a peculiar fragility in the construction of one’s world-model – a breakdown of the high-level coherence that ordinarily binds perception, selfhood, and meaning....