Psychedelic-assisted therapy has emerged as a prominent area for psychiatric investigation particularly with regards to treatment-resistant depression and Post Traumatic Stress Disorder (PTSD). The purpose of this narrative review was to outline the current body of research regarding psychedelic and psychedelic-like compounds in these two psychiatric conditions highlighting psilocybin-assisted...
O uso de ayahuasca vem se expandindo no Brasil para além do contexto religioso tradicional, alcançando também padrões recreativos, com riscos psiquiátricos ainda pouco documentados na literatura nacional. Este relato descreve o caso de uma paciente de 28 anos, com Transtorno Afetivo Bipolar (CID-10 F31.2) diagnosticado havia nove anos e três internações prévias por mania psicótica, internada...
Humans rely on spatial representations to process both temporal duration and mentally project themselves across time. Yet, it remains unclear whether this spatial-temporal mapping depends on embodied mechanisms or on abstract attentional codes. We investigated whether embodied cues (gaze direction) versus abstract cues optokinetic stimulation (OKS) modulate Mental Time Travel (MTT) and age...
Background. Self-criticism and dependency are established personality vulnerabilities for mood and anxiety disorder onset. Although dispositional mindfulness is associated with lower depressive and anxiety symptoms, its preventive role in disorder onset remains unclear. The present study examined whether dispositional mindfulness facets predict first onset of mood and anxiety disorders, and how...
NeuroscienceAugust 30, 2026Yang Wang, Sinem Cetinkaya Karaca, Mille Deckmann Rasmussen et al.
Classical psychedelics exert therapeutic effects on affective disorders, with serotonin 5-HT2A receptor activation thought to play a central role. The cellular mechanisms by which 5-HT2A signaling modulates neural circuits remain incompletely understood and may differ across mood-regulating brain regions. While psychedelic actions have been extensively studied in the medial prefrontal cortex,...
Fentanyl is the leading cause of fatal overdoses worldwide, and repeated use may lead to substance use disorder (SUD). In SUD, drug-associated contexts can trigger reward-related behavior even in the absence of the drug. Psychedelic compounds may weaken context-drug associations, reducing reward-related behavior to fentanyl. We evaluated the effects of the psychedelic psilocin and its...
This work introduces the Critical Reconstructability Corridor (CRC) hypothesis, a theoretical, computational, and empirically testable framework for investigating consciousness-relevant neural dynamics beyond the conventional notion of a single “edge of chaos.” The central proposal is that biological dynamics capable of supporting consciousness may occupy a bounded, multidimensional and...
The amygdala is a key structure within the medial temporal lobe involved in emotional processing, fear responses, social behaviour, and stress regulation, and growing evidence suggests that structural and functional alterations of the amygdala contribute to several psychiatric disorders. This case report and systematic review with meta-analysis examined the relationship between amygdala anatomy...
AIM Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the frontal-limbic overmodulation model and the defense cascade model) have been proposed to interpret dissociative symptoms,...
This paper investigates the potential of nonlinear time-delay networks (NTDNs) in simulating aspects of human consciousness. The core claim is that by constructing networks with intricate nonlinear time-delay dependencies, it may be possible to model fundamental features of consciousness, such as subjective experience and contextual awareness. The proposed mechanism involves designing an NTDN...