5-MeO-DMT: all studies (page 25) - The Consciousness Library

Determination of N,N-dimethyltryptamine in Mimosa tenuiflora inner barks by matrix solid-phase dispersion procedure and GC–MS

Journal of Chromatography B November 17, 2011 Alain Gaujac, Adriano Aquino, Sandro Navickiene et al. 30 citations

N,N-dimethyltryptamine (DMT) is a potent hallucinogen found in beverages consumed in religion rituals and neo-shamanic practices over the world. Two of these religions, Santo Daime and União do Vegetal (UDV), are represented in countries including Australia, the United States and several European nations. In some of this countries there have been legal disputes concerning the legalization of...

DOI: 10.1016/j.jchromb.2011.11.014 Ayahuasca Detection limit Chromatography Matrix chemical analysis +3

Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.

Pharmacology, Biochemistry, and Behavior September 1, 2011 Jerrold C Winter, D J Amorosi, Kenner C Rice et al. 10 citations

In previous studies we have observed that, in comparison with wild type mice, Tg-CYP2D6 mice have increased serum levels of bufotenine [5-hydroxy-N,N-dimethyltryptamine] following the administration of 5-MeO-DMT. Furthermore, following the injection of 5-MeO-DMT, harmaline was observed to increase serum levels of bufotenine and 5-MeO-DMT in both wild-type and Tg-CYP2D6 mice. In the present...

DOI: 10.1016/j.pbb.2011.05.015 Full text Drug interaction Synergism Potentiation Enhancement +25

Nonlinear pharmacokinetics of 5-methoxy-N,N-dimethyltryptamine in mice.

Drug Metabolism and Disposition July 1, 2011 Hong-Wu Shen, Xi-Ling Jiang, Ai-Ming Yu 29 citations

5-Methoxy-N,N,-dimethyltryptamine (5-MeO-DMT), an abused serotonergic indolealkylamine drug, was placed into Schedule I controlled substance status in the United States as of January 19, 2011. In previous studies, we have shown the impact of monoamine oxidase A and cytochrome P450 2D6 enzymes on 5-MeO-DMT metabolism and pharmacokinetics. The aim of this study was to investigate 5-MeO-DMT...

DOI: 10.1124/dmd.111.039107 Full text 5-MEO-DMT Nonlinear pharmacokinetics Drug metabolism Animal research

In vivo long-term kinetics of radiolabeled n,n-dimethyltryptamine and tryptamine.

Journal of Nuclear Medicine June 2011 Arturo A Vitale, Alicia B Pomilio, Carlos O Cañellas et al.

N,N-dimethyltryptamine (DMT), a strong psychodysleptic drug, has been found in higher plants, shamanic hallucinogenic beverages, and the urine of schizophrenic patients. The aim of this work was to gain better knowledge on the relationship between this drug and hallucinogenic processes by studying DMT behavior in comparison with tryptamine. (131)I-labeled DMT and tryptamine were injected into...

DOI: 10.2967/jnumed.110.083246 Full text

5-methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive deficits in rat after exposure in adolescence.

Physiology & Behavior May 3, 2011 David M. Compton, Kerri L. Dietrich, Melissa C. Selinger et al. 21 citations

Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is rapidly gaining popularity among recreational users as a hallucinogenic "designer drug." Unfortunately, much remain unknown about the consequences of its use on neuropsychological development or behavior. During one of two adolescent periods, the rats were given repeated injections of 5 mg/kg or 20 mg/kg...

DOI: 10.1016/j.physbeh.2011.01.021 Full text

Esrar Kullanımı Sırasında Başlayan ve N, N- Dimetiltriptamin (Dmt) Kullanımı ile Psikotik Özellikler Eklenen Duygudurum Bozukluğu: Bir Olgu Sunumu / A Mood Disorder Episode with an Onset Under Chronic Cannabis Consumption, and Accompanied With Psychotic Features Immediately After N,N-Dimethyltryptamine (Dmt) Use: A Case Report

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences April 21, 2011 Gökhan Umut, İlker Küçükparlak, Güliz Özgen et al. 2 citations

A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryptamine (DMT) use: case report N,N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD).Synthetic production of DMT as well as extraction from several plants of South American flora is possible.DMT...

DOI: 10.5350/dajpn2011240312 Full text

Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia.

Neuropharmacology 2011 Maarten Van den Buuse, Emma Ruimschotel, Sally Martin et al. 37 citations

Serotonin-1A (5-HT(1A)) receptors may play a role in schizophrenia and the effects of certain antipsychotic drugs. However, the mechanism of interaction of 5-HT(1A) receptors with brain systems involved in schizophrenia, remains unclear. Here we show that 5-HT(1A) receptor knockout mice display enhanced locomotor hyperactivity to acute treatment with amphetamine, a widely used animal model of...

DOI: 10.1016/j.neuropharm.2011.04.001 Full text Schizophrenia research Psychosis model Mental health Brain disorders +12

Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.

Current Drug Metabolism October 1, 2010 Hong-Wu Shen, Xi-Ling Jiang, Jerrold C Winter et al. 171 citations

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenine, while it is mainly inactivated through the deamination...

DOI: 10.2174/138920010794233495 Full text Psychedelic Metabolism: 5-MEO-DMT Bufotenine Transform Metabolized +11

Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics.

Biochemical Pharmacology July 1, 2010 Hong-Wu Shen, Chao Wu, Xi-Ling Jiang et al. 40 citations

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural psychoactive indolealkylamine drug that has been used for recreational purpose. Our previous study revealed that polymorphic cytochrome P450 2D6 (CYP2D6) catalyzed 5-MeO-DMT O-demethylation to produce active metabolite bufotenine, while 5-MeO-DMT is mainly inactivated through deamination pathway mediated by monoamine oxidase (MAO). This...

DOI: 10.1016/j.bcp.2010.02.020 Full text Drug metabolism Biotransformation Pharmacokinetics Drug processing +13

Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.

Journal of Chromatography A August 14, 2009 Cláudia P.B. Martins, Sally Freeman, John F. Alder et al. 11 citations

The psychoactive properties of N,N-dimethyltryptamine (DMT) are known to induce altered states of consciousness in humans. These properties attract great interest from clinical, neuroscientific, clandestine and forensic communities. The Breath of Hope Synthesis was reported on an internet website as a convenient two-step methodology for the preparation of DMT. The analytical characterisation of...

DOI: 10.1016/j.chroma.2009.06.060 Full text

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