Journal of chromatography. A - The Consciousness Library

Untargeted analysis of psilocybin and non-psilocybin mushrooms using liquid chromatography quadrupole time of flight mass spectrometry.

Journal of chromatography. A July 19, 2025 Sabrina Islam, Tiffany Liden, Roman Goff et al. 1 citation

Psilocybin mushrooms, particularly those containing the psychoactive compounds psilocybin and psilocin, have attracted recent attention due to their potential therapeutic use for the treatment of psychological disorders. To use psilocybin mushrooms in a clinical context, it is important to understand their chemical composition more fully. An untargeted analysis using liquid chromatography (LC)...

DOI: 10.1016/j.chroma.2025.466009 Full text Magic mushrooms Food chemistry Multivariate analysis Untargeted analysis +4

Innovative disposable pipette extraction for concurrent analysis of fourteen psychoactive substances in drug users' sweat.

Journal of chromatography. A August 16, 2024 Nayna Cândida Gomes, Oscar G Cabrices, Bruno Spinosa de Martinis 12 citations

Widespread consumption of drugs of abuse worldwide has caused concern: it adversely affects public health, individual safety, and social structures. Experts are particularly alarmed because new psychoactive substances have been increasingly detected in biological samples. In recent years, several studies have focused on developing methods to identify psychoactive substances in alternative...

DOI: 10.1016/j.chroma.2024.465136 Full text Dpx-scx Gc-ms Psychoactive substances Sweat +8

Systematic characterization of Lysergic Acid Diethylamide metabolites in Caenorhabditis elegans by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry.

Journal of chromatography. A October 11, 2023 Christiane Martins de Vasconcellos Silveira, Vanessa Farelo Dos Santos, Isis Moraes Ornelas et al. 3 citations

Psychedelic compounds have gained renewed interest for their potential therapeutic applications, but their metabolism and effects on complex biological systems remain poorly understood. Here, we present a systematic characterization of Lysergic Acid Diethylamide (LSD) metabolites in the model organism Caenorhabditis elegans using state-of-the-art analytical techniques. By employing ultra-high...

DOI: 10.1016/j.chroma.2023.464362 Full text LSD Uhplc-hrms/ms Psychedelics hallucinogens Psychedelic drugs +7

Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice.

Journal of chromatography. A July 28, 2017 David Fabregat-Safont, M Barneo-Muñoz, F Martinez-Garcia et al. 24 citations

New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common groups, which try to mimic the effects of the natural compounds 9Δ-tetrahydrocannabinol and cathinone, respectively. Similarly, synthetic tryptamines are designer compounds which...

DOI: 10.1016/j.chroma.2017.06.010 Full text 5-MEO-Mipt In vivo studies Metabolite identification New psychoactive substances +1

Analysis of Salvinorin A in plants, water, and urine using solid-phase microextraction-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry.

Journal of chromatography. A February 24, 2012 Brian B Barnes, Nicholas H Snow 25 citations

Salvinorin A, a psychoactive hallucinogen, and related compounds, were analyzed in plants, water, and urine using liquid-liquid extraction (LLE), solid-phase microextraction (SPME) and comprehensive two-dimensional gas chromatography-time of flight mass spectrometry (GC×GC-ToFMS). A semi-qualitative study of the extraction of Salvinorin A and analogs from Salvia divinorum plants by LLE showed...

DOI: 10.1016/j.chroma.2011.09.056 Full text Salvinorin a detection Salvinorin a quantification Spme-ms Solid-phase microextraction +17

Direct analysis of psychoactive tryptamine and harmala alkaloids in the Amazonian botanical medicine ayahuasca by liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal of chromatography. A December 18, 2009 Ethan H. Mcilhenny, Kelly E Pipkin, Leanna J Standish et al. 58 citations

A direct injection/liquid chromatography-electrospray ionization-tandem mass spectrometry procedure has been developed for the simultaneous quantitation of 11 compounds potentially found in the increasingly popular Amazonian botanical medicine and religious sacrament ayahuasca. The method utilizes a deuterated internal standard for quantitation and affords rapid detection of the alkaloids by a...

DOI: 10.1016/j.chroma.2009.10.088 Full text Ayahuasca Analytical chemistry Mass spectrometry Psychoactive compounds

Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.

Journal of chromatography. A August 14, 2009 Cláudia P.B. Martins, Sally Freeman, John F. Alder et al. 11 citations

The psychoactive properties of N,N-dimethyltryptamine (DMT) are known to induce altered states of consciousness in humans. These properties attract great interest from clinical, neuroscientific, clandestine and forensic communities. The Breath of Hope Synthesis was reported on an internet website as a convenient two-step methodology for the preparation of DMT. The analytical characterisation of...

DOI: 10.1016/j.chroma.2009.06.060 Full text

Comparison of the separation of nine tryptamine standards based on gas chromatography, high performance liquid chromatography and capillary electrophoresis methods.

Journal of chromatography. A February 15, 2008 Man-Juing Wang, Ju-Tsung Liu, Hung-Ming Chen et al. 12 citations

Nine tryptamines, including alpha-methyltryptamine (AMT), N,N-dimethyltryptamine (DMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT), N,N-dibutyltryptamine (DBT), N,N-diisopropyltryptamine (DIPT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) were selected as model compounds....

DOI: 10.1016/j.chroma.2007.12.031 Full text

Determination of ibogaine in plasma by gas chromatography--chemical ionization mass spectrometry.

Journal of chromatography. A February 2, 1996 F R Ley, A R Jeffcoat, B F Thomas 18 citations

Ibogaine is naturally occurring indole alkaloid that is currently being considered as a treatment medication for drug dependence. Although there have been a variety of investigations regarding the mechanisms of action and pharmacology of ibogaine, relatively little has been reported regarding quantitative methods. Because of the paucity of analytical methodologies, studies involving the...

DOI: 10.1016/0021-9673(95)00827-6 Full text

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