John F. Alder - The Consciousness Library

Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.

Journal of chromatography. A August 14, 2009 Cláudia P.B. Martins, Sally Freeman, John F. Alder et al. 11 citations

The psychoactive properties of N,N-dimethyltryptamine (DMT) are known to induce altered states of consciousness in humans. These properties attract great interest from clinical, neuroscientific, clandestine and forensic communities. The Breath of Hope Synthesis was reported on an internet website as a convenient two-step methodology for the preparation of DMT. The analytical characterisation of...

DOI: 10.1016/j.chroma.2009.06.060 Full text

Halogenated solvent interactions with N,N-dimethyltryptamine: formation of quaternary ammonium salts and their artificially induced rearrangements during analysis.

Forensic Science International July 4, 2008 Simon D. Brandt, Cláudia P.B. Martins, Sally Freeman et al. 10 citations

The psychoactive properties of N,N-dimethyltryptamine (DMT) 1a are known to induce altered states of consciousness in humans. This particular attribute attracts great interest from a variety of scientific and also clandestine communities. Our recent research has confirmed that DMT reacts with dichloromethane (DCM), either as a result of work-up or storage to give a quaternary N-chloromethyl...

DOI: 10.1016/j.forsciint.2008.03.013 Full text

N,N-Dimethyltryptamine and dichloromethane: Rearrangement of quaternary ammonium salt product during GC–EI and CI-MS–MS analysis

Journal of Pharmaceutical and Biomedical Analysis December 28, 2007 Simon D. Brandt, Cláudia P.B. Martins, Sally Freeman et al. 10 citations

N,N-Dimethyltryptamine (DMT) 1 is a simple tryptamine derivative with powerful psychoactive properties. It is abundant in nature and easily accessible through a variety of synthetic routes. Most work-up procedures require the use of organic solvents and halogenated representatives are often employed. DMT was found to be reactive towards dichloromethane, either during work-up or long term...

DOI: 10.1016/j.jpba.2007.12.024 Dichloromethane Tryptamine Gas chromatography–mass spectrometry Indole test +3

Analytical chemistry of synthetic routes to psychoactive tryptamines : Part II. Characterisation of the Speeter and Anthony synthetic route to N,N-dialkylated tryptamines using GC-EI-ITMS, ESI-TQ-MS-MS and NMR

The Analyst 2005 Simon D. Brandt, Sally Freeman, Ian A. Fleet et al. 46 citations

The degree of alkylation of the side chain nitrogen in tryptamines is one important factor that affects psychoactivity. The method of Speeter and Anthony is considered to be one of the most important synthetic preparative methods. The final step in this reaction is based on the reduction of a (substituted) indole-3-yl-glyoxalylamide to the desired tryptamine with metal hydride. Twelve...

DOI: 10.1039/b413014f Tryptamines Mass spectrometry Conformational isomerism Chemical shift +9

Analytical chemistry of synthetic routes to psychoactive tryptamines : Part III. Characterisation of the Speeter and Anthony route to N,N-dialkylated tryptamines using CI-IT-MS-MS

The Analyst 2005 Simon D. Brandt, Sally Freeman, Ian A. Fleet et al. 10 citations

Twelve symmetrically and 13 asymmetrically N,N-disubstituted glyoxalylamide precursors and their corresponding tryptamine derivatives have been characterised by gas chromatography low-pressure chemical ionisation ion trap tandem mass spectrometry (CI-IT-MS-MS) with internal (in situ) ionisation using methanol as the chemical ionisation reagent. Mass spectral differences and similarities between...

DOI: 10.1039/b504001a Tryptamines Iminium Tandem mass spectrometry Chemical ionization +7

Analytical chemistry of synthetic routes to psychoactive tryptamines : Part I. Characterisation of the Speeter and Anthony synthetic route to 5-methoxy-N,N-diisopropyltryptamine using ESI-MS-MS and ESI-TOF-MS

The Analyst 2004 Simon D. Brandt, Sally Freeman, Ian A. Fleet et al. 27 citations

5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), a new psychoactive tryptamine derivative, has been synthesised by the Speeter and Anthony procedure. This synthetic route was characterised by ESI-MS-MS, ESI-TOF-MS and NMR. Side products have been identified as 3-(2-N,N-diisopropylamino-ethyl)-1H-indol-5-ol (5), 2-N,N-diisopropylamino-1-(5-methoxy-1H-indol-3-yl)-ethanol (6),...

DOI: 10.1039/b407239c Tryptamines Synthetic cannabinoids Ethanol Derivative finance +3