Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia.
Neuropharmacology 2011 Maarten Van den Buuse, Emma Ruimschotel, Sally Martin et al. 37 citations
Serotonin-1A (5-HT(1A)) receptors may play a role in schizophrenia and the effects of certain antipsychotic drugs. However, the mechanism of interaction of 5-HT(1A) receptors with brain systems involved in schizophrenia, remains unclear. Here we show that 5-HT(1A) receptor knockout mice display enhanced locomotor hyperactivity to acute treatment with amphetamine, a widely used animal model of...
DOI: 10.1016/j.neuropharm.2011.04.001 (opens in new tab)
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Schizophrenia research
Psychosis model
Mental health
Brain disorders
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