Current Drug Metabolism

ISSN 1875-5453

2 papers in the library · 283 citations · publishing 2010

Papers

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Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.

Current Drug Metabolism October 1, 2010 Hong-Wu Shen, Xi-Ling Jiang, Jerrold C Winter et al. 171 citations

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenine, while it is mainly inactivated through the deamination...

DOI: 10.2174/138920010794233495 Full text Psychedelic Metabolism: 5-MEO-DMT Bufotenine Transform Metabolized +11

Metabolism of designer drugs of abuse: an updated review.

Current Drug Metabolism June 1, 2010 Markus R Meyer, Hans H Maurer 112 citations

This paper reviews the metabolism of new designer drugs of abuse that have emerged on the black market during the last years and is an update of a review published in 2005. The presented review contains data concerning the so-called 2C compounds (phenethylamine type) such as 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B), 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I),...

DOI: 10.2174/138920010791526042 Full text Drug metabolism Pharmacokinetics Biotransformation Metabolites +19