5-MeO-DMT: all studies (page 106) - The Consciousness Library

Serotonin receptor activation in rats previously deprived of REM sleep.

Pharmacology, Biochemistry, and Behavior April 1, 1983 R Santos, E A Carlini 25 citations

The effects of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan, with or without MAO inhibitors) and of agonists (quipazine and 5-methoxy-N,N-dimethyltryptamine-MeO-DMT) were studied in 3 day REM-deprived or control rats, by recording the presence of the serotonin syndrome and the number of head shakes. The REM sleep-deprived rats showed a larger incidence of the serotonin syndrome...

DOI: 10.1016/0091-3057(83)90271-x Full text

Effects of chronic administration of antidepressant drugs on central serotonergic receptor mechanisms

Palgrave Macmillan UK eBooks 1983 Sven Ove Ögren, Kjell Fuxé, Odd‐geir Berge et al. 11 citations

The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral evidence for sub- and supersensitivity depending on 5-HT agonist dose and types of behavior examined. Thus, chronic treatment with all three drugs reduced head twitches induced by a high dose of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine...

DOI: 10.1007/978-1-349-06689-6_7 Serotonergic Desipramine Imipramine Antidepressant +4

Serotonin involvement in aversive conditioning: reversal of the fear retention deficit by long-term p-chloroamphetamine but not p-chlorophenylalanine.

Neuroscience Letters December 23, 1982 T Archer, S O Ogren, S B Ross 24 citations

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a serotonin (5-HT) agonist, fenfluramine and p-chloroamphetamine (PCA), which are 5-HT releasers, produce deficits in fear retention as indicated by a notable lack of the immobility resulting from inescapable shocks. Depletion of central 5-HT neurones after long-term PCA treatment (2 X 10 mg/kg) completely blocked the retention impairment resulting...

DOI: 10.1016/0304-3940(82)90095-7 Full text

Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.

Life Sciences December 6, 1982 J A Clemens, M E Roush 8 citations

The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT. Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic...

DOI: 10.1016/0024-3205(82)90740-8 Full text

Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines.

Neuropharmacology October 1, 1982 R A Shephard, D A Buxton, P L Broadhurst 59 citations

Interactions between 5-methoxy, N,N-dimethyltryptamine (5-MeODMT), chlordiazepoxide and para-chlorophenylalanine (pCPA) on conflict behaviour were studied. 5-Methoxy, N,N-dimethyltryptamine (1.0 and 3.0 mg/kg), induced observable effects and reduced unpunished response rates but did not affect punished behaviour either alone, on in the presence of 5 or 10 mg/kg chlordiazepoxide. However,...

DOI: 10.1016/0028-3908(82)90117-4 Full text

Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.

European Journal of Pharmacology February 26, 1982 C P Vandermaelen, George K. Aghajanian 37 citations

Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to...

DOI: 10.1016/0014-2999(82)90242-4 Full text

Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for ?hallucinogens?

Psychopharmacology February 1, 1982 Jon Koerner, James B. Appel 19 citations

Fifteen rats were trained to discriminate between the tryptamine hallucinogen psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine; 1.0 mg/kg) and saline in a two-lever choice task. Dose-response and time-response curves were obtained. The psilocybin cue generalized to psilocin (the dephosphorylated congener of psilocybin) and to the prototypical indoleamine hallucinogen LSD, but not to the...

DOI: 10.1007/bf00435266 Psilocybin Mescaline Hallucinogen Tryptamine +2

Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.

Life Sciences February 1, 1982 Richard A Glennon, R Young, F Benington et al. 8 citations

Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater...

DOI: 10.1016/0024-3205(82)90463-5 Full text

Neurophysiological effects of hallucinogens on serotonergic neuronal systems.

Neuroscience & Biobehavioral Reviews 1982

Low intravenous doses of the hallucinogen d-lysergic acid diethylamide (LSD) markedly suppress the discharge of serotonin (5-HT)-containing neurons in the dorsal raphe nucleus of the rat. Microiontophoretically applied LSD also inhibits the firing of 5-HT neurons, indicating that the inhibitory effect is mediated directing on 5-HT neurons. Forebrain neurons receiving a major serotonergic input...

DOI: 10.1016/0149-7634(82)90033-1

Prevention of the serotonin syndrome in rats by repeated administration of monoamine oxidase inhibitors but not tricyclic antidepressants.

Psychopharmacology 1982 I Lucki, A Frazer 91 citations

The serotonin syndrome, a behavioral response produced by the activation of serotonin receptors, and 3H-serotonin binding were examined after repeated treatment of rats with different types of antidepressant drugs. The serotonin syndrome was produced by the direct-acting serotonin receptor agonists 5-methoxy-N,N-dimethyltryptamine (5-MeDMT) or d-lysergic acid diethylamide (LSD). Repeated, but...

DOI: 10.1007/BF00464567 Full text

Research