Frontiers in Psychiatry
July 17, 2026
Shu-Ping Fang, Xin Yang, Da-Cong Zhao et al.
Introduction Substance use disorder (SUD) is a major global health issue, contributing significantly to the disease burden. Despite this, effective treatments for SUD remain limited. Ketamine has shown potential as a treatment, yet no meta-analysis has assessed its efficacy for SUD. This study aimed to evaluate the efficacy and safety of ketamine in treating SUD. Methods Multiple databases were...
Substance Use & Misuse
July 15, 2026
Parvin Ajami Bakhtiarvand, Mohammad Reza Abedi
Substance use disorders (SUDs) affect the lives of more than 35 million people worldwide, according to 2019 data from the United Nations Office on Drugs and Crime. Current evidence suggests that MBIs may mitigate the harmful psychosocial effects associated with SUDs. Although MBIs have been extensively studied for efficacy, there remains a growing need to synthesize evidence from relevant...
July 12, 2026
Fahd François Hilal, Méléna Dreinaza, Quentin Lebel et al.
Background and Purpose: Ketamine has emerged as a promising treatment candidate for alcohol use disorder (AUD), yet whether its S- and R-enantiomers differentially regulate ongoing binge-like alcohol self-administration remains unknown. We compared the acute and repeated effects of S- and R-ketamine in a chronic binge-like, front-loaded operant alcohol self-administration paradigm. Experimental...
Human Arenas
July 10, 2026
Attila Kovács
Abstract Gaming addiction is a complex phenomenon that extends beyond behavioral reinforcement and neurochemical dysregulation. This study adopts a phenomenological approach, integrating Husserl’s active and passive synthesis with Heidegger’s existential structures and Arvidson’s conceptualization of attention, to explore how gaming addiction reshapes reflective awareness, attentional control...
Frontiers in Psychiatry
July 9, 2026
Alqassem Y. Hakami
Background Substance use disorders (SUDs) and treatment-resistant depression (TRD) remain a major global health challenge, marked by high relapse rates and limited long-term effectiveness of existing treatments. Ketamine, a glutamatergic modulator with rapid neuroplastic effects, has emerged as a novel intervention for TRD and is increasingly investigated as an adjunctive treatment for...
Expert Opinion on Drug Discovery
July 4, 2026
Christopher D. Verrico, Lynnette A. Averill, Cameron J Moore et al.
INTRODUCTION: Ibogaine is a naturally occurring indole alkaloid with suggested therapeutic potential across substance use disorders, trauma-related conditions, mood disorders, and suicidality. However, its clinical translation has been hindered by safety concerns, regulatory barriers, and uncertainty regarding its complex pharmacology. Recent interest has surged in developing ibogaine analogs...
The journal of spinal cord medicine
July 1, 2026
Reyhane Sarabandi, Omsalimeh Roudi Rashtabadi, Roghayeh Mehdipour-Rabori et al.
to investigating the effectiveness of a Mindfulness-Based Stress Reduction (MBSR) intervention on resilience, quality of life (QoL), and individual independence in individuals with spinal cord injury (SCI). In this randomized clinical trial, 56 individuals with SCI were recruited through convenience sampling and randomly assigned to intervention and control groups. The intervention group...
BMJ Open
July 1, 2026
Kirsten Morley, Shalini Arunogiri, Katherine L. Mills et al.
INTRODUCTION: The treatment of comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) is significantly more challenging than the treatment of either disorder alone. While gold standard evidence-based treatments exist for this comorbidity, clinically significant improvements are only observed in approximately half of clinical trial participants. The use of adjunctive...
Revista CienciaUANL
July 1, 2026
Armando Ordaz‐hernández, M. Corona-Ramírez, Israel Jesús Orlando Guerrero
La psilocibina, presente en los “hongos mágicos”, y la 5-MeO-DMT, secretada por el sapo Incilius alvarius, fueron empleadas ancestralmente en rituales espirituales en México. Hoy, la ciencia las reconoce como terapias prometedoras contra depresión, ansiedad, estrés postraumático y adicciones resistentes a tratamientos convencionales. Actúan sobre receptores de serotonina y estimulan la...