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6 results for "Meta-analysis: What did research on DMT find in March 2026?"

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In-silico toxicity study of tryptamine, psilocin, psilocybin, N,N-dimethyltryptamine, 5'-methoxy-N,N-dimethyltryptamine and O-acetylpsilocin.

Archives of Toxicology March 31, 2026 Kamil Jurowski, Damian Kobylarz, Maciej Noga

Understanding the toxicity of serotonergic tryptamines is becoming increasingly important from both clinical and forensic perspectives, yet experimental data for these compounds remain extremely limited. Despite their growing medical relevance and widespread non-medical use, there is still no systematic evaluation of their toxicological risks. This study presents the first comprehensive in...

DOI: 10.1007/s00204-026-04365-4 (opens in new tab) Full text (opens in new tab) In silico toxicology Computational toxicology Forensic toxicology Tryptamines

Dose-dependent pharmacokinetics and acute effects of intravenous bolus N,N-dimethyltryptamine: double-blind, randomized versus open-label dose-escalation administration study in healthy participants

Translational Psychiatry March 27, 2026 Livio Erne, Lorenz Mueller, Isabelle Straumann et al.

N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that produces short-lived peak effects when administered intravenously as a bolus dose. Initial trials suggested therapeutic effects of DMT in depressive disorders. However, systematic data on dose-dependent pharmacokinetics and acute effects of intravenous bolus DMT administration are currently lacking. We used a double-blind,...

DOI: 10.1038/s41398-026-03987-7 (opens in new tab) Full text (opens in new tab) Tolerability Pharmacokinetics Crossover study Placebo +7

Isotopic DMT as a Probe of Spinorial Consciousness

Zenodo (CERN European Organization for Nuclear Research) March 11, 2026

We propose a decisive experimental protocol to test the hypothesis that the psychedelic state involves the radical pair mechanism (RPM) operating at the serotonin 5-HT2A receptor. The key insight is that the psychedelic ligand itself — N,N-dimethyltryptamine (DMT, C12 H16 N2 ) — is the source of the hyperfine fields driving the singlet-triplet oscillation. By synthesizing isotopically labelled...

DOI: 10.5281/zenodo.18965901 (opens in new tab) Kinetic isotope effect Deuterium Isotopomers Hyperfine structure +9

Computational evaluation of aluminum and zinc doped C20 fullerenes as advanced sensors for the detection of the narcotic dimethyltryptamine

Scientific Reports March 9, 2026 Saad M. Alshahrani

N, N-Dimethyltryptamine (N, N-DMT) is a potent psychedelic substance whose detection is crucial in medical and forensic contexts. In this study, we computationally evaluate the potential of aluminum- and zinc-doped C20 fullerenes (AlC19 and ZnC19) as advanced sensors for N, N-DMT detection. Using density functional theory (DFT) and time-dependent DFT, along with NBO, NCI, RDG, and ESP analyses,...

DOI: 10.1038/s41598-026-41537-9 (opens in new tab) Full text (opens in new tab) Adsorption Fullerene Absorption acoustics Density functional theory +7

Nuclear Spin Modulation of Psychedelic Consciousness States: A Factorial fMRI Protocol Combining N,N-DMT with Krypton and Xenon Isotopes

Zenodo (CERN European Organization for Nuclear Research) March 4, 2026

The discovery that xenon isotopes with non-zero nuclear spin are ∼30% less po-tent as anesthetics than spin-zero isotopes (Li et al., 2018) established a link betweenquantum spin and consciousness. Independently, N,N-dimethyltryptamine (DMT)induces profoundly altered conscious states characterized by global hyperconnec-tivity and apparent “channel switching” (Timmermann et al., 2023;...

DOI: 10.5281/zenodo.18866486 (opens in new tab) Krypton Isotopes of xenon Atomic physics Spin aerodynamics +2