Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons.
S M Evans, C E Johanson
Drug and Alcohol Dependence October 1986 DOI: 10.1016/0376-8716(86)90048-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Drug discrimination study (animal behavioral pharmacology experiment) Peer reviewed |
|---|---|
| Population | Pigeons trained in a two-key food-maintained drug discrimination paradigm |
| Interventions | (+)-Amphetamine MDMA MDA |
| Dose | MDMA 3.0 mg/kg; MDA 3.0 or 5.6 mg/kg |
| Topics | MDMA |
| Key findings | MDMA (3.0 mg/kg) and MDA (3.0 or 5.6 mg/kg) substituted for (+)-amphetamine in pigeons trained to discriminate amphetamine from saline, indicating similar discriminative stimulus effects. MDA produced a greater decrease in response rate than AMPH or MDMA at these doses, and both MDMA and MDA were less potent than AMPH. |
Abstract
Pigeons trained to discriminate (+)-amphetamine (AMPH) from saline in a two-key food-maintained drug discrimination paradigm, were used to investigate the discriminative stimulus (DS) effects of two structural analogues of amphetamine, namely (+/-)-3,4-methylenedioxymethamphetamine (MDMA) and (+/-)-3,4-methylenedioxyamphetamine (MDA). After discrimination performance was stable (90% injection-appropriate responding), test sessions with various doses of AMPH were conducted and a dose-dependent relationship for AMPH-appropriate responding was obtained. Both MDMA (3.0 mg/kg) and MDA (3.0 or 5.6 mg/kg) substituted for AMPH; however, at these doses MDA produced a greater decrease in response rate compared to AMPH and MDMA. Furthermore, while MDMA and MDA were similar in potency in producing drug-appropriate responding, both were less potent than AMPH. These results indicate that MDMA and MDA have DS effects similar to AMPH in pigeons.
Comparable studies
Other experimental studies on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin | 2000 | Experimental study | |
| Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Rat brain | 1988 | Experimental study | |
| The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Human platelet plasma membrane vesicles and bovine adrenal chromaffin granule membrane... | 1992 | Laboratory study | |
| Oxytocin-dependent reopening of a social reward learning critical period with MDMA | 2019 | Experimental study | |
| Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes Rat whole brain synaptosomes | 1982 | Experimental study |
Citations in the library
Cited by 21
- 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans Addiction May 1, 1994
- A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (±)-MDMA in rats. Experimental and Clinical Psychopharmacology 2000
- History of MDMA Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA 1990
- MDMA and memory: the acute and chronic effects of MDMA in pigeons performing under a delayed-matching-to-sample procedure Psychopharmacology February 1, 1993
- Methylenedioxymethamphetamine-like discriminative stimulus effects of seven cathinones in rats Behavioural Pharmacology June 1, 2020
and 16 more in the library
Cites 3
- The effects of (+/-)-methylenedioxymethamphetamine and (+/-)-methylenedioxyamphetamine in monkeys trained to discriminate (+)-amphetamine from saline. Drug and Alcohol Dependence October 1, 1986
- Further investigation of the discriminative stimulus properties of MDA. Pharmacology, Biochemistry, and Behavior April 1984
- MDA: a psychoactive agent with dual stimulus effects. Life Sciences January 23, 1984