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Further investigation of the discriminative stimulus properties of MDA.

Richard A Glennon, R Young

Pharmacology, Biochemistry, and Behavior April 1984 DOI: 10.1016/0091-3057(84)90295-8 (opens in new tab)

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AI-extracted from the abstract
Characteristics Drug discrimination study in rats Peer reviewed
Population Rats trained in a two-lever drug discrimination task
Interventions (+)-Amphetamine (+/-)-MDA S(+)-MDA R(-)-MDA
Key points Amphetamine stimulus generalization occurred to S(+)-MDA but not R(-)-MDA. Together with earlier findings of DOM generalization to R(-)-MDA but not S(+)-MDA, the authors suggest S(+)-MDA's stimulus effects are predominantly amphetamine-like and R(-)-MDA's are more DOM-like, so rats trained on racemic MDA appear to recognize both classes.

Abstract

Rats trained to discriminate either (+)-amphetamine or (+/-)-MDA from saline in a two-lever drug discrimination task, were used to study the stimulus effects of MDA and its two optical isomers. Amphetamine-stimulus generalization occurred to S(+)-MDA, but not to its enantiomer R(-)-MDA. This, coupled with our earlier finding of DOM-stimulus generalization to R(-)-MDA but not to S(+)-MDA, suggests that the stimulus effects of S(+)-MDA are predominantly amphetamine-like while those of R(-)-MDA are more DOM-like. Thus, animals trained to discriminate racemic MDA from saline can apparently recognize members of both classes of agents.

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