MDA: a psychoactive agent with dual stimulus effects.
Life Sciences January 23, 1984 DOI: 10.1016/0024-3205(84)90627-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Drug discrimination study in rats Peer reviewed |
|---|---|
| Population | Rats trained in a two-lever drug discrimination task |
| Interventions | (+)-Amphetamine Racemic MDA DOM |
| Dose | 1.0 mg/kg (+)-amphetamine; 1.5 mg/kg racemic MDA |
| Key points | The amphetamine stimulus generalized to MDA but not DOM, while the MDA stimulus generalized to both amphetamine and DOM. Together with prior findings that DOM generalizes to MDA but not amphetamine, the authors suggest MDA produces dual stimulus effects in animals. |
Abstract
Rats were trained to discriminate injections of either (+)-amphetamine (1.0 mg/kg) or racemic MDA (1.5 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances (greater than 85%) were attained in each group, stimulus generalization studies were conducted. The amphetamine-stimulus generalized to MDA, but not to the hallucinogenic agent DOM; the MDA-stimulus generalized to both amphetamine and DOM. Taken together with our previous finding that DOM-stimulus generalization occurs to MDA but not to amphetamine, the present study suggests that MDA is capable of producing dual stimulus effects in animals. In addition to these salient features, the results of this study also have an impact on stimulus specificity, and further emphasize the importance of thorough dose-response relationships as related to tests of stimulus generalization.
Citations in the library
Cited by 28
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
- Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity Journal of Neuroscience August 1, 1988
- ECSTACY: A Review of MDMA and MDA The International Journal of Psychiatry in Medicine December 1, 1987
- Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy Journal of Psychopharmacology September 10, 2020
- MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology Current Neuropharmacology August 1, 2013
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Cites 6
- Methylenedioxyamphetamine (MDA)–Subjective Effects Journal of Psychedelic Drugs 1974
- MDA-ASSISTED PSYCHOTHERAPY WITH NEUROTIC OUTPATIENTS The Journal of Nervous and Mental Disease October 1, 1976
- Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists. European Journal of Pharmacology July 1, 1983
- MDA and DOM: substituted amphetamines that do not produce amphetamine-like discriminative stimuli in the rat. Psychopharmacology 1980
- The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM): differentiation from amphetamine. Psychopharmacology 1980
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