ASSAY OF LYSERGIC ACID DIETHYLAMIDE AND ITS PASSAGE FROM BLOOD INTO THE PERFUSED CEREBRAL VENTRICLES
M. Draskoci
British Journal of Pharmacology and Chemotherapy 1960 DOI: 10.1111/j.1476-5381.1960.tb01206.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Isolated rat uterus; cats |
| Intervention | lysergic acid diethylamide |
| Dose | 2x10(-8) concentration for oxytocic action; 10(-9) to 10(-10) for potentiation; intravenous infusion at 10 mug./min./kg in cats |
| Topics | LSD |
| Citations | 1 |
| Key findings | LSD potentiates acetylcholine-induced contractions in the isolated rat uterus at concentrations that do not themselves stimulate contractions, and this effect allows measurement of LSD entering the cerebral ventricles in cats. |
Abstract
On the isolated rat uterus, lysergic acid diethylamide had an oxytocic action in a concentration of 2x10(-8); in smaller concentrations (10(-9) to 10(-10)), which had no stimulating effect of their own, it potentiated acetylcholine-induced contractions. This potentiating effect was made the basis for assaying minute amounts of lysergic acid diethylamide. The method was used to assay this substance in plasma of cats during its intravenous infusion at a rate of 10 mug./min./kg. During these infusions 0.4 to 2 ng./min. of lysergic acid diethylamide passed into the cerebral ventricles perfused with a salt solution of a composition resembling that of cerebrospinal fluid.
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| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
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