Lysergic acid diethylamide: evidence for stimulation of cerebral dopamine receptors
M. Da Prada, A. Saner, W.p. Burkard, G. Bartholini, A. Pletscher
Brain Research August 1, 1975 DOI: 10.1016/0006-8993(75)90877-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats and cats |
| Intervention | Lysergic acid diethylamide (LSD) |
| Topics | LSD |
| Keywords | Homovanillic acid Caudate nucleus Stimulation Dopamine receptor Endocrinology Adenylate kinase Central nervous system |
| Citations | 71 |
| Key findings | LSD stimulates dopamine receptors in the central nervous system, which may be involved in LSD-induced psychosis. |
Abstract
In the rat, lysergic acid diethylamide (LSD) decreased the striatal and retinal content of homovanillic acid. LSD did not change the level of dopamine (DA), but delayed the a-methyl-p-tyrosine-induced disappearance of this amine in the teldiencephalon. In the cat, LSD diminished the DA output into the perfusate of the caudate nucleus. Furthermore, LSD increased the activity of adenylate cyclase in striatal homogenates of rat. These and other findings indicate that in the central nervous system LSD stimulates DA receptors which may be involved in LSD-induced phychosis.